Allergic bronchopulmonary mycosis in patients with asthma: period prevalence at a university hospital in Saudi Arabia
Allergic bronchopulmonary mycosis in patients with asthma: period prevalence at a university hospital in Saudi Arabia
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DOI：
10.1053/rmed.2001.1047
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发表时间：
2001-05-01
影响因子：
4.3
通讯作者：
Joharjy, I
中科院分区：
文献类型：
--
作者：
Al-Mobeireek, AF;El-Rab, MOG;Joharjy, I
过敏性支气管肺真菌病 (ABPM) 是一种已知的哮喘并发症，可导致进行性肺损伤、呼吸衰竭和死亡。哮喘是沙特阿拉伯的一种常见疾病，迄今为止，ABPM 的患病率尚未得到调查。本研究的目的是估计哮喘患者中由曲霉菌和念珠菌引起的 ABPM 的患病率。地点是沙特阿拉伯中部地区一所大学医院的肺部门诊。对 264 名连续哮喘患者（150 名或 57% 女性）进行了评估。所有患者均使用一组真菌抗原通过皮肤点刺试验 (SPT) 进行 ABPM 筛查。皮肤反应阳性者进一步进行临床、免疫学检查。呼吸器？和放射学评估。在 264 名患者中，根据 Rosenberg 于 1977 年提出的至少 5 条主要标准，即可诊断 ABPM。 62 人 (23%) 至少一种真菌过敏原 SPT 呈阳性，其中 44 人 (71%) 为女性 (P = 0(.)01)。七名患者（六名女性）因曲霉菌和（或）念珠菌属而被诊断为 ABPM。因此，我们估计 ABPM 的周期患病率为 2(.)7%（95% 置信区间 1(.)3-5(.)4%）。黑曲霉是我们组中分离出的最常见的真菌物种。总之，ABPM 在沙特阿拉伯并不罕见，女性似乎面临更大的风险。由于哮喘很常见，因此医生需要对这种疾病保持高度怀疑，并通过适当的测试进行诊断。
Allergic bronchopulmonary mycosis (ABPM) is a known complication of asthma and can result in progressive lung damage, respiratory failure and death. Asthma is a common disease in Saudi Arabia and until now the prevalence of ABPM has not been investigated. The aim of this study was to estimate the period prevalence of ABPM due to Aspergillus and Candida in patients with asthma. The setting was an outpatient pulmonary clinic at a university hospital in the central region of Saudi Arabia. Two hundred and sixty-four consecutive patients with asthma (150 or 57% females) were evaluated. All patients were screened for ABPM with skin prick test (SPT) using a panel of fungal antigens. Those with positive skin reactions had further clinical, immunological. respirator?; and radiological assessment. ABPM was diagnosed by the presence of a minimum of five of the major criteria suggested by Rosenberg in 1977. Of the 264 patients. 62 (23%) had a positive SPT for at least one fungal allergen, of whom 44 (71%) were females (P = 0(.)01). Seven patients (six females) were diagnosed with ABPM due to Aspergillus and (or) Candida species. Therefore, we estimate the period prevalence of ABPM to be 2(.)7% (95% confidence interval 1(.)3-5(.)4%). A. niger was the commonest fungal species isolated in our group. Tn conclusion, ABPM is not uncommon in Saudi Arabia and females seem to be more at risk. Because asthma is common, physicians need to have high index of suspicion for this disease and pursue the diagnosis with the appropriate tests.