Activity in the medial temporal lobe predicts memory strength, whereas activity in the prefrontal cortex predicts recollection.
Activity in the medial temporal lobe predicts memory strength, whereas activity in the prefrontal cortex predicts recollection.
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DOI：
10.1523/jneurosci.3456-08.2008
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发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Squire LR
中科院分区：
文献类型：
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作者：
Kirwan CB;Wixted JT;Squire LR
功能性磁共振成像（FMRI）对识别记忆的研究通常被解释为海马体支持回忆，而邻近的鼻周皮层支持熟悉。其他研究表明，这些研究混淆了强记忆和弱记忆的回忆和熟悉程度。在一项源记忆研究中，我们使用了两种新颖的数据分析方法，允许独立评估项目记忆强度和源记忆强度。首先，我们确定了海马体和周围皮层的活动随后续项目记忆强度的变化而变化的区域，而源记忆强度在偶然水平上保持不变。其次，我们确定了前额叶皮层中活动随后续源记忆强度而变化的区域，而项目记忆强度保持不变。这些发现表明，内侧颞叶的活动预测了随后的记忆强度，而前额叶皮层的活动预测了随后的回忆。
FMRI studies of recognition memory have often been interpreted to mean that the hippocampus supports recollection and that the adjacent perirhinal cortex supports familiarity. Other work suggests that these studies have confounded recollection and familiarity with strong and weak memories. In a source memory study, we used two novel approaches to data analysis that allowed item memory strength and source memory strength to be assessed independently. First, we identified regions in both hippocampus and perirhinal cortex where activity varied as a function of subsequent item memory strength while source memory strength was held constant at chance levels. Second, we identified regions in prefrontal cortex where activity varied as a function of subsequent source memory strength while item memory strength was held constant. These findings suggest that activity in the medial temporal lobe is predictive of subsequent memory strength, whereas activity in prefrontal cortex is predictive of subsequent recollection.