Neuroendocrine aspects of primary endogenous depression. VII. Logistic regression analysis of matched patient-control hormone data for discrimination between groups.
Neuroendocrine aspects of primary endogenous depression. VII. Logistic regression analysis of matched patient-control hormone data for discrimination between groups.
复制标题
原发性内源性抑郁症的神经内分泌方面。
DOI：
10.1016/0022-3956(88)90038-6
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发表时间：
1988
影响因子：
4.8
通讯作者：
Poland,RE
中科院分区：
文献类型：
--
作者：
Rubin,RT;Wheeler,NC;Pregibon,D;Poland,RE
我们先前报道了40例原发的RDC明确的内源性抑郁症患者的下丘脑-垂体-肾上腺皮质(HPA)和甲状腺(HPT)轴功能的显著改变，与40名单独匹配的正常对照受试者相比。在这些报告中，对匹配样本使用了单变量统计检验(配对t检验)。接下来，我们希望在多变量分析中同时使用HPA和HPT来区分患者和对照组，但激素数据的配对性质排除了使用标准技术的可能性。通过对BMDP PLR统计程序的修改，我们以逐步的方式进行了匹配的Logistic回归分析，得到了一个包含两个HPA变量和一个HPT变量的模型。从这个模型中，我们估算了抑郁与否与HPA和HPT指标水平之间的优势比。40对配对的中位数优势比为7.8。为了说明这个模型，我们给出了选择荷尔蒙数值的患者与荷尔蒙数值接近我们研究中40名对照组的中位数的典型正常受试者的估计优势比曲线图。
We previously reported significant alterations in hypothalamo-pituitary-adrenal cortical (HPA) and thyroid (HPT) axis function in a group of 40 primary, RDC definite endogenous depressives compared to 40 individually matched normal control subjects. In those reports, univariate statistical tests for matched samples were used (pairedt-tests). We next wished to use both the HPA and the HPT measures in a multivariate analysis to discriminate the patients from the controls, but the paired nature of the hormone data obviated the use of standard techniques. With an adaptation of the BMDP PLR statistical program, we performed a matched logistic regression analysis, in stepwise fashion, which resulted in a model incorporating two HPA variables and one HPT variable. From this model, odds ratios which associate being depressed or not with levels of the HPA and HPT measures were estimated. The median odds ratio for the 40 matched pairs was 7.8. To illustrate the model, we present graphs of estimated odds ratios of patients with selected hormone values compared to a typical normal subject with hormone values close to the median values of the 40 controls in our study.