A persistent cellular change in a single modulatory neuron contributes to associative long-term memory
A persistent cellular change in a single modulatory neuron contributes to associative long-term memory
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DOI：
10.1016/s0960-9822(03)00380-4
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发表时间：
2003-06-17
期刊：
影响因子：
9.2
通讯作者：
Benjamin, PR
中科院分区：
文献类型：
--
作者：
Jones, NG;Kemenes, I;Benjamin, PR
大多数神经元学习模型假设突触强度的变化是长期记忆（LTM）形成的主要机制[1]。然而，我们在这里表明，一个持久的去极化膜电位，一种类型的细胞变化，增加神经元的反应，有助于显着持久的联想记忆痕迹。使用具有已识别神经元和已知突触连接性的模型无脊椎动物网络的优点在于，可以在学习电路中具有已知功能的神经元中评估这种细胞变化对记忆的贡献。具体而言，我们使用了充分理解的软体动物摄食运动回路[2-4]，并表明参与摄食运动起始的关键调节神经元[5]在行为关联条件反射后经历了长期去极化[6]。这种去极化导致增强的单细胞和网络的反应，以前中性的触觉条件刺激，和持久性相匹配的时间过程中的行为联想记忆。一个关键的调节神经元的膜电位的变化是足够的和必要的，以启动条件反射在减少准备，并强调其重要性的关联LTM。
Most neuronal models of learning assume that changes in synaptic strength are the main mechanism underlying long-term memory (LTM) formation [1]. However, we show here that a persistent depolarization of membrane potential, a type of cellular change that increases neuronal responsiveness, contributes significantly to a long-lasting associative memory trace. The use of a model invertebrate network with identified neurons and known synaptic connectivity had the advantage that the contribution of this cellular change to memory could be evaluated in a neuron with a known function in the learning circuit. Specifically, we used the well-understood motor circuit underlying molluscan feeding [2-4] and showed that a key modulatory neuron involved in the initiation of feeding ingestive movements [5] underwent a long-term depolarization following behavioral associative conditioning [6]. This depolarization led to an enhanced single cell and network responsiveness to a previously neutral tactile conditioned stimulus, and the persistence of both matched the time course of behavioral associative memory. The change in the membrane potential of a key modulatory neuron is both sufficient and necessary to initiate a conditioned response in a reduced preparation and underscores its importance for associative LTM.