Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus
Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus
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DOI：
10.1128/jvi.74.10.4919-4928.2000
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发表时间：
2000-05-01
影响因子：
5.4
通讯作者：
Rose, TM
中科院分区：
文献类型：
--
作者：
Schultz, ER;Rankin, GW;Rose, TM
我们已经克隆和其特征在于整个DNA聚合酶基因和侧翼区卡波西肉瘤相关疱疹病毒（KSHV）和两个密切相关的猕猴同源KSHV，腹膜后纤维瘤病相关疱疹病毒，猕猴nemestrina（RFHVMn）和猕猴mulatta（RFHVMm）。我们还鉴定并部分表征了另一种KSHV样疱疹病毒的相应基因组区域，暂时命名为“M。Nemestrina rhadinovirus type 2（MneRV-2），与恒河猴rhadinovirus（RRV）非常相似。对这四种猕猴病毒和最近在非洲绿色猴中发现的两种KSHV样γ疱疹病毒（Chlorocebus rhadinovirus 1型和2型（ChRV-1和ChRV-2））的序列比较显示，在旧大陆灵长类动物中存在两种不同的KSHV样rhadinovirus谱系。第一个Rhadinovirus谱系由KSHV及其密切相关的同源物RFHVMn，RFHVMm和ChRV-1组成，而第二个更远相关的谱系由RRV，MneRV-2和ChRV-2组成，我们的研究结果提出了另一种属于第二个Rhadinovirus谱系的人KSHV样疱疹病毒存在的可能性。
We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina (RFHVMn) and -Macaca mulatta (RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named "M. nemestrina rhadinovirus type 2 (MneRV-2)," with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2, Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage.