Severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in Uganda
Severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in Uganda
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DOI：
10.1093/jn/131.11.2843
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Semba, RD
中科院分区：
文献类型：
--
作者：
Shah, S;Whalen, C;Semba, RD
虽然结核病和人体免疫机能丧失病毒（艾滋病毒）合并感染正在成为许多发展中国家的一个主要问题，但结核病和艾滋病毒感染的成年人的营养状况还没有得到很好的描述。我们采用人体测量和生物电阻抗分析，比较了乌干达坎帕拉261例HIV阳性和278例HIV阴性肺结核成人的营养状况。在163名HIV阳性和199名HIV阴性男性中，细胞内水与细胞外水（ICW：ECW）的比值分别为1.48 +/- 0.26和1.59 +/- 0.48（P = 0.006），相位角分别为5.42 +/- 1.05和5.76 +/- 1.30（P = 0.009）。在98例HIV阳性和79例HIV阴性女性中，ICW：ECW分别为1.19 +/- 0.16和1.23 +/- 0.15（P = 0.11），相位角分别为5.35 +/- 1.27和5.43 +/- 0.93（P = 0.61）。HIV阳性和HIV阴性成人的BMI、体细胞质量、脂肪质量或去脂肪质量无显著差异。在HIV阳性受试者中，CD 4（+）淋巴细胞小于或等于200个细胞/穆尔的受试者的BMI、ICW：ECW、体细胞质量、脂肪质量和相位角显著低于大于200个细胞/穆尔的受试者。在撒哈拉以南非洲，肺结核和艾滋病毒的合并感染与较小的体细胞质量和细胞内水有关，但与无脂肪质量无关，并且与ICW：ECW和相位角α的巨大差异有关。
Although coinfection with tuberculosis and human immunodeficiency virus (HIV) is emerging as a major problem in many developing countries, nutritional status has not been well characterized in adults with tuberculosis and HIV infection. We compared nutritional status between 261 HIV-positive and 278 HIV-negative adults with pulmonary tuberculosis in Kampala, Uganda, using anthropometry and bioelectrical impedance analysis. Among 163 HIV-positive and 199 HIV-negative men, intracellular water-to-extracellular water (ICW:ECW) ratio was 1.48 +/- 0.26 and 1.59 +/- 0.48 (P = 0.006) and phase angle was 5.42 +/- 1.05 and 5.76 +/- 1.30 (P = 0.009), respectively. Among 98 HIV-positive and 79 HIV-negative women, ICW:ECW was 1.19 +/- 0.16 and 1.23 +/- 0.15 (P = 0.11) and phase angle was 5.35 +/- 1.27 and 5.43 +/- 0.93 (P = 0.61), respectively. There were no significant differences in BMI, body cell mass, fat mass or fat-free mass between HIV-positive and HIV-negative adults. Among HIV-positive subjects, BMI, ICW:ECW, body cell mass, fat mass and phase angle were significantly lower among those with CD4(+) lymphocytes less than or equal to 200 cells/muL compared with those who had > 200 cells/muL. In sub-Saharan Africa, coinfection with pulmonary tuberculosis and HIV is associated with smaller body cell mass and intracellular water, but not fat-free mass, and by large differences in ICW:ECW and phase angle alpha.