Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
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DOI：
10.1016/s0304-3940(99)00463-2
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发表时间：
1999-07-23
影响因子：
2.5
通讯作者：
Nagatsu, T
中科院分区：
文献类型：
--
作者：
Mogi, M;Togari, A;Nagatsu, T
采用高灵敏的双抗体夹心酶联免疫吸附试验(EL ISA)，首次检测了正常对照组和帕金森病患者脑(黑质、尾状核、壳核、小脑和额叶皮质)脑源性生长因子(BDNF)的浓度。帕金森病患者脑组织中的脑源性神经营养因子(ng/mg蛋白的数量级)在黑质纹状体多巴胺(DA)区明显低于对照组。帕金森病患者黑质中神经生长因子(NGF)的浓度也明显低于对照组。由于BDNF和NGF可能在神经细胞的存活和分化中发挥重要作用，目前的资料表明，在黑质纹状体DA神经元退行性变的过程中，神经营养因子，特别是BDNF的缺乏可能参与了帕金森病的发病机制。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
Using highly sensitive sandwich enzyme-linked immunosorbent assays (ELISA), we measured for the first time the concentrations of brain-derived growth factor (BDNF) in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients. BDNF in the human brain (the order of ng/mg protein) was significantly lower specifically in the nigrostriatal dopamine (DA) regions from parkinsonian patients than in those from control patients. The concentration of nerve growth factor (NGF) was also significantly decreased in the substantia nigra of parkinsonian patients in comparison with that in the controls. Since BDNF and NGF may play important roles in survival and differentiation of neuronal cells, the present data indicate that the lack of neurotrophins, especially BDNF, may be involved in the pathogenesis of PD during progress of neurodegeneration of the nigrostriatal DA neurons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.