The effect of ketogenic diet on behaviors and synaptic functions of naive mice
The effect of ketogenic diet on behaviors and synaptic functions of naive mice
复制标题
生酮饮食对幼鼠行为和突触功能的影响
DOI：
10.1002/brb3.1246
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发表时间：
2019-04-01
影响因子：
3.1
通讯作者：
Sun, Xiang-Dong
中科院分区：
文献类型：
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作者：
Huang, Jie;Li, Yuan-Quan;Sun, Xiang-Dong
除了作为癫痫治疗的应用外，生酮饮食（KD）还被认为是各种其他神经和代谢疾病的潜在治疗方法。然而，KD是否通过减少个体疾病的病理过程或通过一些独立的机制促进功能恢复尚不清楚。方法观察KD对幼年小鼠一系列行为学和突触功能的影响。用对照饮食或KD喂养2-3月龄的野生型C57 BL/6 J小鼠三个月。在整个实验过程中监测体重和热量摄入。我们通过癫痫发作诱导、运动协调和活动、焦虑水平、空间学习和记忆、社交能力和抑郁来评估行为表现。还记录了突触传递和长时程增强。结果KD组小鼠的行为学和电生理学表现与对照组相当，但体重增加较慢，癫痫发作阈值增加。结论我们的结果有助于更好地了解KD对生理行为和突触功能的影响。
Introduction Beyond its application as an epilepsy therapy, the ketogenic diet (KD) has been considered a potential treatment for a variety of other neurological and metabolic disorders. However, whether KD promotes functional restoration by reducing the pathological processes underlying individual diseases or through some independent mechanisms is not clear. Methods In this study, we evaluated the effect of KD on a series of behaviors and synaptic functions of young adult naive mice. Wild-type C57BL/6J mice at age of 2-3 months were fed with control diet or KD for three months. Body weight and caloric intake were monitored throughout the experiments. We assessed behavioral performance with seizure induction, motor coordination and activity, anxiety level, spatial learning and memory, sociability, and depression. Synaptic transmission and long-term potentiation were also recorded. Results KD-fed mice performed equivalent to control-diet-fed mice in the behavioral tests and electrophysiological assays except exhibiting slower weight gain and increased seizure threshold. Conclusions Our results contribute to the better understanding of effects of the KD on physiological behaviors and synaptic functions.