Genetic control of cell fate in the termini of the Drosophila embryo.
Genetic control of cell fate in the termini of the Drosophila embryo.
复制标题
果蝇胚胎末端细胞命运的遗传控制。
DOI：
10.1016/0012-1606(92)90254-e
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发表时间：
1992
影响因子：
2.7
通讯作者：
Lipshitz,HD
中科院分区：
文献类型：
--
作者：
Strecker,TR;Yip,ML;Lipshitz,HD
果蝇胚胎前后端细胞的命运是由多个合子基因控制的，这些合子基因受母体编码的信号转导通路的调控。这些基因指定终端不同于中央细胞的命运，程序模式沿着前后和背腹轴的终端，也控制内胚层规格和终端形态发生的运动。在这里，我们使用的遗传相互作用测试，解剖合子组件的终端遗传层次。我们发现两个基因，linesandempty spiracles，作用于tailless的下游，抑制中央和促进终端细胞的命运沿着前后轴的终端。控制末端背腹图案的基因和控制末端形态发生的基因在独立于无尾的遗传层次的不同分支中起作用。
Cell fates in the anterior and posterior termini of theDrosophilaembryo are programmed by multiple zygotic genes that are regulated in response to a maternally encoded signal transduction pathway. These genes specify terminal as distinct from central cell fates, program pattern along the anteroposterior and dorsoventral axes of the termini, and also control endoderm specification and terminal morphogenetic movements. Here, we use a genetic interaction test to dissect the zygotic components of the terminal genetic hierarchy. We show that two genes,linesandempty spiracles, act downstream oftaillessto repress central and promote terminal cell fates along the anteroposterior axis of the termini. Genes that control dorsoventral pattern in the termini and genes that program terminal morphogenesis act in distinct branches of the genetic hierarchy that are independent oftailless.