Pathways leading to an immunological disease: systemic lupus erythematosus.
Pathways leading to an immunological disease: systemic lupus erythematosus.
复制标题
DOI：
10.1093/rheumatology/kew427
复制
发表时间：
2017-04-01
期刊：
影响因子：
--
通讯作者：
Davis LS
中科院分区：
文献类型：
--
作者：
Zharkova O;Celhar T;Cravens PD;Satterthwaite AB;Fairhurst AM;Davis LS
系统性红斑狼疮（SLE）是一种由免疫系统紊乱引起的慢性自身免疫性疾病。临床表现是异质性的，主要是因为多种遗传和环境因素导致疾病的发生和进展。在过去的60年里，我们对驱动疾病过程的免疫机制的理解有了一些重大的飞跃。我们现在知道，多种白细胞亚群，以及炎症细胞因子，趋化因子和调节介质，通常参与宿主保护免受入侵病原体，有助于炎症事件导致组织破坏和器官衰竭。在这个广泛的概述中，我们讨论了参与SLE的主要途径，并强调了新的发现。我们描述了这种形式的自身免疫的免疫学变化的特点。讨论了疾病进展所必需的主要白细胞，以及传播免疫反应和驱动SLE炎症反应的关键介质。
SLE is a chronic autoimmune disease caused by perturbations of the immune system. The clinical presentation is heterogeneous, largely because of the multiple genetic and environmental factors that contribute to disease initiation and progression. Over the last 60 years, there have been a number of significant leaps in our understanding of the immunological mechanisms driving disease processes. We now know that multiple leucocyte subsets, together with inflammatory cytokines, chemokines and regulatory mediators that are normally involved in host protection from invading pathogens, contribute to the inflammatory events leading to tissue destruction and organ failure. In this broad overview, we discuss the main pathways involved in SLE and highlight new findings. We describe the immunological changes that characterize this form of autoimmunity. The major leucocytes that are essential for disease progression are discussed, together with key mediators that propagate the immune response and drive the inflammatory response in SLE.