The effects of radiation therapy on the macrophage response in cancer.
The effects of radiation therapy on the macrophage response in cancer.
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DOI：
10.3389/fonc.2022.1020606
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
放射治疗是癌症治疗的主要手段，其疗效受到肿瘤微环境（TME）的细胞和非细胞特征的强烈影响。肿瘤相关巨噬细胞（TAM）是TME内的异质性群体，其患病率与一系列癌症的患者预后显著相关。巨噬细胞具有内在的放射抗性，放射治疗可影响TAM的募集和表型。然而，单独的放射治疗是否可以有效地“重新编程”TAM以显示抗肿瘤表型似乎是矛盾的。在这里，我们讨论了辐射对癌症巨噬细胞募集和可塑性的影响，同时强调了特定TME成分的作用，这些成分可能会损害肿瘤对辐射的反应并影响巨噬细胞功能。特别是，本次审查将集中在可溶性因子（细胞因子，趋化因子和补体系统的组成部分）以及物理变化的TME。由于巨噬细胞的反应有可能影响放射治疗的结果，这个群体可能代表了一个药物的目标，以改善治疗。增强对影响辐射诱导的TAM募集和功能的TME组分的理解可能有助于考虑未来针对这种塑料和普遍人群的治疗途径的范围。
The efficacy of radiotherapy, a mainstay of cancer treatment, is strongly influenced by both cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are a heterogeneous population within the TME and their prevalence significantly correlates with patient prognosis in a range of cancers. Macrophages display intrinsic radio-resistance and radiotherapy can influence TAM recruitment and phenotype. However, whether radiotherapy alone can effectively “reprogram” TAMs to display anti-tumor phenotypes appears conflicting. Here, we discuss the effect of radiation on macrophage recruitment and plasticity in cancer, while emphasizing the role of specific TME components which may compromise the tumor response to radiation and influence macrophage function. In particular, this review will focus on soluble factors (cytokines, chemokines and components of the complement system) as well as physical changes to the TME. Since the macrophage response has the potential to influence radiotherapy outcomes this population may represent a drug target for improving treatment. An enhanced understanding of components of the TME impacting radiation-induced TAM recruitment and function may help consider the scope for future therapeutic avenues to target this plastic and pervasive population.
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影响因子：
56.9
作者：
Jaakkola, P;Mole, DR;Ratcliffe, PJ
通讯作者：
Ratcliffe, PJ
影响因子：
7.3
作者：
Appleton E;Hassan J;Chan Wah Hak C;Sivamanoharan N;Wilkins A;Samson A;Ono M;Harrington KJ;Melcher A;Wennerberg E
通讯作者：
Wennerberg E
影响因子：
3.7
作者：
Crittenden MR;Cottam B;Savage T;Nguyen C;Newell P;Gough MJ
通讯作者：
Gough MJ
影响因子：
15.9
作者：
Imtiyaz, Hongxia Z.;Williams, Emily P.;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
影响因子：
5.1
作者：
Griffiths, L;Binley, K;Naylor, S
通讯作者：
Naylor, S