Molecular mechanisms underlying airway smooth muscle contraction and proliferation: Implications for asthma
Molecular mechanisms underlying airway smooth muscle contraction and proliferation: Implications for asthma
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DOI：
10.1016/j.rmed.2008.02.020
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发表时间：
2008-08-01
影响因子：
4.3
通讯作者：
Marsico, Serafino A.
中科院分区：
文献类型：
--
作者：
Pelaia, Girolamo;Renda, Teresa;Marsico, Serafino A.
气道平滑肌（ASM）在支气管张力以及支气管壁的结构重塑中起关键作用。因此，ASM的收缩和增殖在哮喘的发生和发展中起重要作用。许多收缩激动剂也表现为促有丝分裂刺激，因此有助于构建高反应性和增生性ASM表型。本文将概述兴奋-收缩偶联和ASM细胞生长所涉及的分子机制和信号通路。事实上，在理解ASM生物学的基本方面的最新进展正在揭示重要的细胞靶点，目前正在探索用于实施新的、更有效的抗哮喘疗法。(C)2008年由Elsevier Ltd.出版
Airway smooth muscle (ASM) plays a key rote in bronchomotor tone, as well as in structural remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly participate in the development and progression of asthma. Many contractile agonists also behave as mitogenic stimuli, thus contributing to frame a hyperresponsive and hyperplastic ASM phenotype. In this review, the molecular mechanisms and signaling pathways involved in excitation-contraction coupling and ASM cell growth will be outlined. Indeed, the recent advances in understanding the basic aspects of ASM biology are disclosing important cellular targets, currently explored for the implementation of new, more effective anti-asthma therapies. (C) 2008 Published by Elsevier Ltd.