Granulocyte-macrophage colony-stimulating factor as immunomodulating factor together with influenza vaccination in stem cell transplant patients
Granulocyte-macrophage colony-stimulating factor as immunomodulating factor together with influenza vaccination in stem cell transplant patients
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DOI：
10.1086/313663
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发表时间：
2000-02-01
影响因子：
11.8
通讯作者：
Ljungman, P
中科院分区：
文献类型：
--
作者：
Pauksen, K;Linde, A;Ljungman, P
研究了117例接受干细胞移植（SCT）的患者接种流感疫苗后，粒细胞-巨噬细胞集落刺激因子（GM-CSF）对血清学应答的影响。疫苗应答通过酶联免疫吸附试验（ELISA）检测流感血凝抑制（HAI）抗体和IgG抗体水平的显著升高来评估。64例接种GM-CSF疫苗的患者与53例未接种GM-CSF疫苗的患者相比，对甲型流感或乙型流感的抗体反应没有差异。在同种异体SCT患者亚组中，HAI显示治疗组对乙型流感疫苗的应答率显著高于治疗组（P < 0.05）。ELISA结果显示，自体SCT乳腺癌患者接受GM-CSF后对甲型流感和乙型流感有更好的应答（P < 0.05），在早期接种疫苗，干细胞移植后4-12个月，这些应答更为明显。GM-CSF似乎可以改善某些SCT患者对流感疫苗接种的反应，但只是在有限的程度上。
The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the serological response at influenza vaccination was studied in 117 patients who had undergone stem cell transplantation (SCT), The vaccine response was evaluated as significant increases in levels of influenza hemagglutination-inhibition (HAI) antibodies and of IgG antibodies measured by enzyme-linked immunosorbent assay (ELISA). There was no difference in antibody response to either influenza A or B in 64 patients who received GM-CSF at vaccination, compared with the 53 who did not. In the subgroup of allogeneic SCT patients, HAI showed chat the response rate to the influenza B vaccine was significantly higher in the treatment group (P < .05). ELISA showed that autologous SCT patients with breast cancer who received GM-CSF had a better response to influenza A (P < .05) and B (P < .01), At early vaccination, 4-12 months after stem cell transplantation, these responses were more pronounced. GM-CSF appears to improve the response to influenza vaccination in some groups of SCT patients, but only to a limited extent.