Auditory sensory ("echoic") memory dysfunction in schizophrenia.
Auditory sensory ("echoic") memory dysfunction in schizophrenia.
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DOI：
10.1176/ajp.152.10.1517
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发表时间：
1995-10
期刊：
影响因子：
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通讯作者：
R. Strous;N. Cowan;W. Ritter;D. Javitt
中科院分区：
文献类型：
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作者：
R. Strous;N. Cowan;W. Ritter;D. Javitt
目的 精神分裂症工作记忆功能障碍的研究主要集中在前额叶部分。这项研究调查了听觉感觉（“回声”）记忆的完整性，该部分几乎不依赖于前额叶功能。方法 使用非延迟和延迟音调匹配对 20 名精神分裂症受试者和 20 名年龄和智商匹配的正常对照受试者进行回声记忆研究。结果 精神分裂症受试者在两个音调之间经过极短的延迟（300 毫秒）后，其匹配两种音调的能力明显受损，但当音调之间没有延迟时，则没有受到损害。结论 精神分裂症患者的工作记忆功能障碍会影响前额皮质外部和内部的大脑区域。
OBJECTIVE Studies of working memory dysfunction in schizophrenia have focused largely on prefrontal components. This study investigated the integrity of auditory sensory ("echoic") memory, a component that shows little dependence on prefrontal functioning. METHOD Echoic memory was investigated in 20 schizophrenic subjects and 20 age- and IQ-matched normal comparison subjects with the use of nondelayed and delayed tone matching. RESULTS Schizophrenic subjects were markedly impaired in their ability to match two tones after an extremely brief delay between them (300 msec) but were unimpaired when there was no delay between tones. CONCLUSIONS Working memory dysfunction in schizophrenia affects brain regions outside the prefrontal cortex as well as within.