Genomics analysis of leukaemia predisposition in X‐linked agammaglobulinaemia
Genomics analysis of leukaemia predisposition in X‐linked agammaglobulinaemia
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X连锁无丙种球蛋白血症患者白血病易感性的基因组学分析
DOI：
10.1111/bjh.17459
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发表时间：
2021
影响因子：
6.5
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Nishimura;A. Naruto;T. Miyamoto;S. Grigg;A. Bosco;J. J. Hoshino;A. Amano;K. Iwamoto;S. Hirayama;M. Migita;M. Ohara;O. Takagi;M. Morio;T. van Zelm;M. C. Kanegane;H.
BCP-ALL的XLA患者没有表现出独特的甲基化谱。布鲁顿酪氨酸激酶；急性淋巴母细胞白血病；急性巨核母细胞白血病；肿瘤抑制因子布鲁顿酪氨酸激酶；急性淋巴细胞白血病；急性巨核细胞白血病；X-linked agammaglobulinemia （XLA）是一种由布鲁顿酪氨酸激酶I （BTK I）致病性变异引起的先天性免疫错误。在未来的研究中，许多XLA合并白血病的患者可能能够阐明XLA中白血病细胞的更详细的特征。《英国血液学杂志》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考资料的原始出版版本以获取完整摘要。版权适用于所有摘要。
Abstract BCP-ALL of the XLA patients did not show a distinctive methylation profile. X-linked agammaglobulinemia, Bruton's tyrosine kinase, acute lymphoblastic leukemia, acute megakaryoblastic leukemia, tumor suppressor Keywords: X-linked agammaglobulinemia; Bruton's tyrosine kinase; acute lymphoblastic leukemia; acute megakaryoblastic leukemia; tumor suppressor EN X-linked agammaglobulinemia Bruton's tyrosine kinase acute lymphoblastic leukemia acute megakaryoblastic leukemia tumor suppressor 1277 1281 5 06/18/21 20210615 NES 210615 X-linked agammaglobulinemia (XLA) is an inborn error of immunity caused by pathogenic variants in I Bruton's tyrosine kinase i (I BTK i). Future studies in which many patients with XLA with leukemia are enrolled may be able to clarify the more detailed characteristics of leukaemic cells in XLA.[Extracted from the article]Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.