Antipsychotic-induced weight gain: a review of the literature.
Antipsychotic-induced weight gain: a review of the literature.
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发表时间：
2001-06
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通讯作者：
D. B. Allison;D. Casey
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作者：
D. B. Allison;D. Casey
随着所谓的新型抗精神病药物的可用性，锥体外系症状对精神分裂症患者的影响越来越小，同时，一种新的症状正在成为一个突出的问题。这种副作用是体重增加及其伴随的代谢。本文回顾了目前已知的抗精神病药物引起的体重增加，描述了问题的严重性，简要介绍了作用机制，并阐述了体重增加幅度的个体间变化的相关性。此外，我们还讨论了体重增加对依从性的影响以及体重增加与治疗效果之间是否存在相关性的问题。最后，我们讨论了体重增加的医学后果，并回顾了支持抗精神病药物引起的体重增加的各种治疗方案的文献。正如我们将看到的，这是一个处于起步阶段的研究领域，还有许多工作要做。
With the availability of the so-called novel antipsychotic agents, extrapyramidal symptoms are becoming decreasingly problematic for patients with schizophrenia, and simultaneously, a new symptom is emerging as a preeminent concern. This side effect is weight gain and its metabolic concomitants. This article reviews what is currently known about antipsychotic-induced weight gain, describes the magnitude of the problem, briefly touches on mechanisms of action, and addresses the correlation of interindividual variations in magnitude of weight gain. In addition, we address questions about the effects of weight gain on compliance and whether or not there is a correlation between weight gain and therapeutic efficacy. Finally, we address medical consequences of weight gain and review the literature supporting various treatment options for antipsychotic-induced weight gain. As will be seen, this is an area of research in its infancy, and much work remains to be done.