Gateway reflexes, neuronal circuits that regulate the gateways for autoreactive T cells in organs that have blood barriers.
Gateway reflexes, neuronal circuits that regulate the gateways for autoreactive T cells in organs that have blood barriers.
复制标题
网关反射，是调节具有血液屏障的器官中自身反应性 T 细胞网关的神经元回路。
DOI：
10.1093/intimm/dxab022
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Murakami M.
中科院分区：
文献类型：
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作者：
Uchida M;Yamamoto R;Matsuyama S;Murakami K;Hasebe R;Hojyo S;Tanaka Y;Murakami M.
网关反射是维持免疫系统动态平衡的神经回路。它们为自身反应性T细胞形成通道，以依赖去甲肾上腺素的方式渗透到中枢神经系统，尽管有血脑屏障。这一机制不仅对维持器官动态平衡至关重要，而且对炎症性疾病的发展也至关重要。通道反射可以受到环境或人工刺激(包括电刺激)的调节，这表明免疫细胞的渗透可以通过生物电子药物来控制。在这篇综述中，我们描述了门户反射的发现及其未来的发展方向，特别是生物电子医学。
Gateway reflexes are neural circuits that maintain homeostasis of the immune system. They form gateways for autoreactive T cells to infiltrate the central nervous system in a noradrenaline-dependent manner despite the blood–brain barrier. This mechanism is critical not only for maintaining organ homeostasis but also for inflammatory disease development. Gateway reflexes can be regulated by environmental or artificial stimuli including electrical stimulation, suggesting that the infiltration of immune cells can be controlled by bioelectronic medicine. In this review, we describe the discovery of gateway reflexes and their future directions with special focus on bioelectronic medicine.