Brain states govern the spatio-temporal dynamics of resting-state functional connectivity
Brain states govern the spatio-temporal dynamics of resting-state functional connectivity
复制标题
DOI：
10.7554/elife.53186
复制
发表时间：
2020-06-22
期刊：
影响因子：
7.7
通讯作者：
Stroh, Albrecht
中科院分区：
文献类型：
--
作者：
Aedo-Jury, Felipe;Schwalm, Miriam;Stroh, Albrecht
先前，在麻醉大鼠中使用同时的静息状态功能磁共振成像（fMRI）和基于光度计的神经元钙记录，我们鉴定了与慢钙波直接相关的血氧水平依赖性（BOLD）反应，揭示了局部记录的神经元活动的皮质范围和空间组织相关性（Schwalm等人，2017年）。在这里，使用相同的技术，我们调查两个不同的皮质活动状态：持续活动，其中观察到的分隔网络动态;和慢波活动，主要由一个皮质范围内的BOLD组件，这表明一个强大的功能耦合的皮质间活动。在慢波活动期间，我们发现发生的慢波事件与不同皮层区域之间的功能连接强度之间存在相关性。这些发现表明，神经元兴奋性的上下转换可以驱动整个皮层的功能连接。这项研究提供了进一步的证据，表明功能连接的变化取决于大脑的当前状态，与慢波的产生直接相关。
Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017). Here, using the same techniques, we investigate two distinct cortical activity states: persistent activity, in which compartmentalized network dynamics were observed; and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. During slow wave activity, we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. This study provides further evidence that changes in functional connectivity are dependent on the brain's current state, directly linked to the generation of slow waves.