Anti-Hypercholesterolemic Effect of Dehydroepiandrosterone in Rats
Anti-Hypercholesterolemic Effect of Dehydroepiandrosterone in Rats
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脱氢表雄酮对大鼠的抗高胆固醇血症作用
DOI：
10.3181/00379727-125-32297
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发表时间：
1967
影响因子：
--
通讯作者：
F. Sulman
中科院分区：
文献类型：
--
作者：
M. Ben;S. Dikstein;G. Bismuth;F. Sulman
研究了脱氢表雄酮（DHA）和3α-甲氧基− 17α−甲基− 5α −雄甾烷−17α−01（SC-12790）的抗高胆固醇血症和拟甲状腺活性。研究结果如下：1. DHA（5 mg/kg/d，口服，10天）被发现是一种抗高胆固醇血症剂，其防止了通过丙基硫氧嘧啶（PTU）治疗造成高胆固醇血症的大鼠的血清胆固醇水平（SCL）的增加。研究还发现，在21天的时间内给予相同剂量的DHA，可以防止通过PTU和胆固醇联合喂养造成高胆固醇血症的大鼠的SCL增加。然而，DHA并没有降低正常大鼠的SCL。2.在与DHA相同的实验条件下给予SC-12790时，不会降低高胆固醇血症大鼠的SCL。3. DHA没有产生任何变化，甲状腺重量一样，外源性TSH和T-3。DHA的抗高胆固醇血症作用似乎不能用拟甲状腺活性来解释。这些发现具有临床重要性，因为DHA是一种弱内源性雄激素，作为抗高胆固醇血症剂具有口服活性。并对其可能的作用机制进行了讨论。
Summary Dehydroepiandrosterone (DHA) and 3α-methoxy − 17α−methyl− 5α −androstane−17α−01 (SC-12790) were studied for their anti-hypercholesterolemic and thyromimetic activities. The following findings were established: 1. DHA (5 mg/kg/d per os for 10 days) was found to be an anti-hypercholesterolemic agent which prevented increase in the serum cholesterol level (SCL) of rats made hypercholesterolemic by propylthiouracil (PTU) treatment. It was also found that the same dose of DHA given over a period of 21 days prevented an increase in SCL in rats made hypercholesterolemic by combined PTU and cholesterol feeding. DHA, however, did not reduce the SCL of normal rats. 2. SC-12790, when given under the same experimental conditions as DHA, did not reduce the SCL of hypercholesterolemic rats. 3. DHA did not produce any change in thyroid weight as did exogenous TSH and T-3. It seems that the anti-hypercholesterolemic effect of DHA cannot be explained by a thyromimetic activity. These findings are of clinical importance since DHA, which is a weak endogenous androgen, is orally active as an anti-hypercholesterolemic agent. The possible mechanism of its action is discussed.