Identification of hypothalamic transcripts upregulated by antidepressants.
Identification of hypothalamic transcripts upregulated by antidepressants.
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抗抑郁药上调的下丘脑转录本的鉴定。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
P. Gold
中科院分区：
文献类型：
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作者：
M. Wong;P. Khatri;J. Licinio;A. Esposito;P. Gold
抗抑郁治疗后大脑中发生的基因表达的定量变化的鉴定可以产生新的分子标记物，可能有助于诊断和治疗抑郁症。使用修改的差异显示聚合酶链反应，我们描述了两个转录的差异表达的抗抑郁药给药8周后，在大脑中的隔离，相比盐水处理的对照动物。
Identification of quantitative changes in gene expression that occur in the brain after antidepressant treatment can yield novel molecular markers that may be useful in the diagnosis and treatment of major depression. Using a modification of the differential display polymerase chain reaction, we describe the isolation of two transcripts that are differentially expressed in the brain after an 8-week course of antidepressant administration, compared to saline-treated control animals.