The influence of inlet velocity profile on predicted flow in type B aortic dissection.
The influence of inlet velocity profile on predicted flow in type B aortic dissection.
复制标题
B型主动脉夹层入口速度剖面对预测流量的影响
DOI：
10.1007/s10237-020-01395-4
复制
发表时间：
2021-04
影响因子：
3.5
通讯作者：
Xu XY
中科院分区：
文献类型：
--
作者：
Armour CH;Guo B;Pirola S;Saitta S;Liu Y;Dong Z;Xu XY
为了使计算流体动力学提供定量参数以辅助B型主动脉夹层的临床评估，结果必须准确地模拟主动脉内的血液动力学环境。因此，入口流速曲线（IVP）的选择至关重要;然而，通常采用理想化曲线，并且IVP对夹层主动脉中血流动力学的影响尚不清楚。本研究检查了IVP影响的两种情况-使用（a）患者特异性数据，形式为三向（3D）、通过平面（TP）或平面IVP;和（B）非患者特异性血流波形。使用患者特异性数据从9次模拟中获得的结果表明，所有形式的IVP都能够再现4D流动磁共振成像观察到的全球流动模式。主入口撕裂附近的最大速度和时间平均壁面剪应力的差异分别高达3%和6%，而真腔和假腔的压差差异高达6%。当主要入口撕裂靠近左锁骨下动脉时，在低壁面切应力区域发现了更显著的变化。使用非患者特定波形获得的结果明显不同。在整个主动脉中，每搏输出量减少25%导致速度和壁面切应力分别减少28%和35%，而流量波形的形状对预测压力有深远的影响。本研究的结果表明，3D，TP和平IVP都产生合理相似的速度和时间平均壁面剪应力的结果，但TP IVP应使用在可能的情况下，更好地预测压力。在缺乏患者特定速度数据的情况下，应努力采集患者的每搏输出量并相应调整应用的IVP。
In order for computational fluid dynamics to provide quantitative parameters to aid in the clinical assessment of type B aortic dissection, the results must accurately mimic the hemodynamic environment within the aorta. The choice of inlet velocity profile (IVP) therefore is crucial; however, idealised profiles are often adopted, and the effect of IVP on hemodynamics in a dissected aorta is unclear. This study examined two scenarios with respect to the influence of IVP—using (a) patient-specific data in the form of a three-directional (3D), through-plane (TP) or flat IVP; and (b) non-patient-specific flow waveform. The results obtained from nine simulations using patient-specific data showed that all forms of IVP were able to reproduce global flow patterns as observed with 4D flow magnetic resonance imaging. Differences in maximum velocity and time-averaged wall shear stress near the primary entry tear were up to 3% and 6%, respectively, while pressure differences across the true and false lumen differed by up to 6%. More notable variations were found in regions of low wall shear stress when the primary entry tear was close to the left subclavian artery. The results obtained with non-patient-specific waveforms were markedly different. Throughout the aorta, a 25% reduction in stroke volume resulted in up to 28% and 35% reduction in velocity and wall shear stress, respectively, while the shape of flow waveform had a profound influence on the predicted pressure. The results of this study suggest that 3D, TP and flat IVPs all yield reasonably similar velocity and time-averaged wall shear stress results, but TP IVPs should be used where possible for better prediction of pressure. In the absence of patient-specific velocity data, effort should be made to acquire patient’s stroke volume and adjust the applied IVP accordingly.
登录
查看更多内容
基于 4-D 流 MRI 的患者特异性主动脉夹层血流计算分析
影响因子：
4.6
作者：
Pirola, Selene;Guo, Baolei;Xu, Xiao Yun
通讯作者：
Xu, Xiao Yun
B 型主动脉夹层患者特异性研究：真假腔血液交换的评估
影响因子：
3.9
作者：
Chen D;Müller-Eschner M;von Tengg-Kobligk H;Barber D;Böckler D;Hose R;Ventikos Y
通讯作者：
Ventikos Y
影响因子：
2.4
作者：
Tse, Kwong Ming;Chiu, Peixuan;Ho, Pei
通讯作者：
Ho, Pei
影响因子：
2.4
作者：
Morbiducci, Umberto;Ponzini, Raffaele;Rizzo, Giovanna
通讯作者：
Rizzo, Giovanna
DOI：
10.1115/1.4023132
发表时间：
2013-01-01
影响因子：
1.7
作者：
Kousera, C. A.;Wood, N. B.;Xu, X. Y.
通讯作者：
Xu, X. Y.