The loss of profilin1 is catastrophic to podocytes.
The loss of profilin1 is catastrophic to podocytes.
复制标题
profilin1的缺失对足细胞是灾难性的。
DOI：
10.1172/jci175594
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发表时间：
2023-12-15
影响因子：
15.9
通讯作者：
Mallipattu, Sandeep K.
中科院分区：
文献类型：
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作者：
Mallipattu, Sandeep K.
原肌球调节蛋白1（Profilin1）属于一类小型单体肌动蛋白结合蛋白家族，在细胞存活所必需的、依赖肌动蛋白的基本细胞过程中发挥多种作用。足细胞是终末分化的脏层上皮细胞，对肾脏滤过屏障的结构和功能至关重要。越来越多的证据表明，一种与肌动蛋白相关的细胞死亡方式——有丝分裂灾难，是导致足细胞丢失的重要途径。在本期《临床研究杂志》（JCI）中，田（Tian）、佩迪戈（Pedigo）及其同事证明，足细胞中Profilin1缺失会引发细胞周期再进入，导致胞质分裂失败，核糖体RNA加工受损，进而导致足细胞丢失和肾小球硬化。这项研究揭示了肌动蛋白动力学在介导足细胞这种基本细胞死亡方式中的关键作用。
Profilin1 belongs to a family of small monomeric actin-binding proteins with diverse roles in fundamental actin-dependent cellular processes required for cell survival. Podocytes are postmitotic visceral epithelial cells critical for the structure and function of the kidney filtration barrier. There is emerging evidence that the actin-related mode of cell death known as mitotic catastrophe is an important pathway involved in podocyte loss. In this issue of the JCI, Tian, Pedigo, and colleagues demonstrate that profilin1 deficiency in podocytes triggered cell cycle reentry, resulting in abortive cytokinesis with a loss in ribosomal RNA processing that leads to podocyte loss and glomerulosclerosis. This study demonstrates the essential role of actin dynamics in mediating this fundamental mode of podocyte cell death.