Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine
Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine
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DOI：
10.1073/pnas.1708361114
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发表时间：
2017-07-11
影响因子：
11.1
通讯作者：
Burstein, Rami
中科院分区：
文献类型：
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作者：
Noseda, Rodrigo;Lee, Alice J.;Burstein, Rami
偏头痛患者避免光线，因为光线会加剧他们的头痛。然而，这并不是他们厌恶光线的唯一原因。通过研究偏头痛患者和对照组，我们发现，在偏头痛或对照组中，灯光引发了更多的自主神经功能和负面情绪的变化，而不是在没有偏头痛或对照组的情况下，并且灯光和积极情绪之间的联系在对照组中比偏头痛患者更强。为了确定这些发现的神经解剖学基础，我们发现，在大鼠中，视网膜神经节细胞的轴突会聚在下丘脑神经元上，这些神经元直接投射到脑干和脊髓中的核，这些核调节副交感神经和交感神经功能，并含有多巴胺、组胺、食欲素、黑色素浓缩激素、催产素和加压素。虽然大鼠研究定义了概念化光如何触发患者描述的症状的框架，但人类研究表明，光的厌恶性质比其与头痛加剧的关联更复杂。
Migraineurs avoid light because it intensifies their headache. However, this is not the only reason for their aversion to light. Studying migraineurs and control subjects, we found that lights triggered more changes in autonomic functions and negative emotions during, rather than in the absence of, migraine or in control subjects, and that the association between light and positive emotions was stronger in control subjects than migraineurs. Seeking to define a neuroanatomical substrate for these findings, we showed that, in rats, axons of retinal ganglion cells converge on hypothalamic neurons that project directly to nuclei in the brainstem and spinal cord that regulate parasympathetic and sympathetic functions and contain dopamine, histamine, orexin, melanin-concentrating hormone, oxytocin, and vasopressin. Although the rat studies define frameworks for conceptualizing how light triggers the symptoms described by patients, the human studies suggest that the aversive nature of light is more complex than its association with headache intensification.