Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis.
Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis.
复制标题
高尔基体在癌细胞侵袭和转移中的适应性变化
DOI：
10.3389/fcell.2021.806482
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Bui S;Mejia I;Díaz B;Wang Y
The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration. These roles are partially mediated by well-known Golgi functions, including post-translational modifications, lipid biosynthesis, intracellular trafficking, and protein secretion. In addition, accumulating evidence indicates that the Golgi plays a critical role in sensing and integrating external and internal cues to promote cellular homeostasis. Indeed, the unique structure of the mammalian Golgi can be fine-tuned to adapt different Golgi functions to specific cellular needs. This is particularly relevant in the context of cancer, where unrestrained proliferation and aberrant survival and migration increase the demands in Golgi functions, as well as the need for Golgi-dependent sensing and adaptation to intrinsic and extrinsic stressors. Here, we review and discuss current understanding of how the structure and function of the Golgi apparatus is influenced by oncogenic transformation, and how this adaptation may facilitate cancer cell invasion and metastasis.
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影响因子：
4.6
作者：
Cai X;Thinn AMM;Wang Z;Shan H;Zhu J
通讯作者：
Zhu J
DOI：
10.1016/j.bbrc.2012.08.140
发表时间：
2012-10-05
影响因子：
3.1
作者：
Choi, Hee-Jung;Chung, Tae-Wook;Ha, Ki-Tae
通讯作者：
Ha, Ki-Tae
影响因子：
1.5
作者：
Calvisi, DF;Thorgeirsson, SS
通讯作者：
Thorgeirsson, SS
影响因子：
50.3
作者：
Anh Tuan Nguyen;Chia, Joanne;Bard, Frederic
通讯作者：
Bard, Frederic
ERK8是O-GalNAC糖基化和细胞迁移的负调节剂。
影响因子：
7.7
作者：
Chia J;Tham KM;Gill DJ;Bard-Chapeau EA;Bard FA
通讯作者：
Bard FA