Pancreatic cancer-associated stroma production
Pancreatic cancer-associated stroma production
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DOI：
10.1016/j.amjsurg.2007.05.004
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发表时间：
2007-10-01
影响因子：
3
通讯作者：
Korc, Murray
中科院分区：
文献类型：
--
作者：
Korc, Murray
胰腺导管腺癌（PDAC）的特征之一是广泛的结缔组织增生。促结缔组织增生间质由增殖的成纤维细胞和胰腺星状细胞组成，它们产生。存款纤连蛋白和胶原蛋白、产生趋化因子和细胞因子的炎性细胞和巨噬细胞、释放神经生长因子的神经纤维和骨髓源性干细胞。基质的产生由大量的生长因子促进，包括成纤维细胞生长因子（FGF）、表皮生长因子（EGF）受体配体、转化生长因子-β（TGF-β）同种型和结缔组织生长因子。由于其在胰腺中的位置，基质细胞和胰腺癌细胞也暴露于高胰岛素水平。基质隔室储存并合成多种生长因子和硫酸乙酰肝素蛋白聚糖磷脂酰肌醇蛋白聚糖-1和多配体蛋白聚糖-1。这种独特的微环境窝藏和隐藏癌细胞，促进其侵袭和转移潜力。因此，靶向间质可能为这种致命的恶性肿瘤提供新的治疗选择。(C)2007 Excerpta Medica Inc. All rights reserved.
One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and pancreatic stellate cells that produce and. deposit fibronectin and collagens, inflammatory cells and macrophages that produce chemokines and cyokines, nerve fibers that release nerve growth factors, and marrow-derived stem cells. Stroma production is facilitated by the abundance of growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF) receptor ligands, transforming growth factor-beta (TGF-beta) isoforms, and connective tissue growth factor. Due to its location in the pancreas, stromal cells and pancreatic cancer cells are also exposed to high insulin levels. The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1. This unique microenvironment harbors and nourishes the cancer cells, facilitating their invasive and metastatic potential. Targeting the stroma may thus provide novel therapeutic options in this deadly malignancy. (C) 2007 Excerpta Medica Inc. All rights reserved.