Risk factors for antibiotic-resistant E. coli in children in a rural area.
Risk factors for antibiotic-resistant E. coli in children in a rural area.
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农村地区儿童抗生素耐药性大肠杆菌的危险因素。
DOI：
10.1017/s0950268808001519
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发表时间：
2009
影响因子：
4.2
通讯作者：
Coles,CL
中科院分区：
文献类型：
--
作者：
Seidman,JC;AnithaK,P;Kanungo,R;Bourgeois,AL;Coles,CL
我们调查了印度泰米尔纳德邦农村地区小学生粪便中大肠杆菌的抗菌敏感性。还获得了当地水源中大肠杆菌样品的耐药性概况。我们调查了作为耐药风险因素的社会人口特征和当地儿科处方模式。在 119 个粪便样本中，对 1 种抗生素的耐药性为 63%，多重耐药性为 32%。抵抗结果与就读学校、兄弟姐妹在同一所学校上学、年龄较小和家庭不那么拥挤有关。九个水样中有八个对 1 种抗生素具有抗药性。最近的用药史与耐药性无关。耐药模式可能受到当地儿科处方模式和兽用抗生素使用的影响。对共生耐药性进行频繁、低成本的监测可以指导制定适合当地的治疗指南。应将学校卫生计划视为限制抗生素耐药性传播的手段。
We surveyed antimicrobial susceptibility in faecal Escherichia coli in primary schoolchildren in rural Tamil Nadu, India. Resistance profiles of E. coli samples from local water sources were also obtained. We investigated sociodemographic characteristics as risk factors for resistance and local paediatric prescription patterns. In 119 stool samples, carriage of resistance to ⩾1 antibiotic was 63% and multiple drug resistance was 32%. Resistance outcomes were associated with school of attendance, having a sibling attend the same school, younger age, and less crowded households. Eight of nine water samples were resistant to ⩾1 antibiotic. Recent history of medication use was not associated with resistance carriage. Resistance patterns may have been influenced by local paediatric prescription patterns and veterinary antibiotic use. Frequent, low-cost surveillance of commensal resistance can guide development of locally appropriate treatment guidelines. School-based hygiene programmes should be considered as means of limiting the spread of antibiotic resistance.