Social networks and HCV viraemia in anti-HCV-positive rural drug users.
Social networks and HCV viraemia in anti-HCV-positive rural drug users.
复制标题
抗 HCV 阳性农村吸毒者的社交网络和 HCV 病毒血症。
DOI：
10.1017/s0950268812000696
复制
发表时间：
2013
影响因子：
4.2
通讯作者：
Havens,JR
中科院分区：
文献类型：
--
作者：
Young,AM;Jonas,AB;Havens,JR
虽然已知社交网络在与丙型肝炎病毒（HCV）感染相关的吸毒行为中发挥重要作用，但有关社交网络和HCV的文献并不一致。本探索性研究检测了阿巴拉契亚农村抗HCV阳性非医疗处方阿片类药物使用者（NMPOU）社交网络中HCV RNA的分布。参与者进行血清学检测HCV RNA，并使用访谈管理的问卷调查收集行为，人口统计学和网络数据。使用逻辑回归进行多变量分析。行为和人口统计学特征没有不同的RNA状态。在多变量模型中，近期注射毒品使用者（IDUs）更可能是RNA阳性[比值比（OR）4.06，95%置信区间（CI）1.04 - 15.83]，转入IDU的毒品网络具有显著保护作用（OR 0.15，95%CI 0.03 - 0.75）。这是迄今为止第一项从网络角度研究农村NMPOUs中HCV分布的研究，并表明网络特征显着有助于HCV在这一研究不足的高危人群中的流行病学。
Although social networks are known to play an important role in drug-using behaviours associated with hepatitis C virus (HCV) infection, literature on social networks and HCV is inconsistent. This exploratory study examined HCV RNA distribution within a social network of anti-HCV-positive non-medical prescription opioid users (NMPOUs) in rural Appalachia. Participants were tested serologically for HCV RNA, and behavioural, demographic, and network data were collected using interview-administered questionnaires. Multivariate analyses were performed using logistic regression. Behavioural and demographic characteristics did not differ by RNA status. In the multivariate model, recent injecting drug users (IDUs) were more likely to be RNA positive [odds ratio (OR) 4·06, 95% confidence interval (CI) 1·04–15·83], and turnover into an IDU's drug network was significantly protective (OR 0·15, 95% CI 0·03–0·75). This is the first study to date to examine HCV distribution in rural NMPOUs from a network perspective and demonstrates that network characteristics significantly contribute to the epidemiology of HCV in this understudied, high-risk population.