Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW)
Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW)
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DOI：
10.1039/b915113c
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发表时间：
2009-01-01
期刊：
影响因子：
6.1
通讯作者：
Huang, Tony Jun
中科院分区：
文献类型：
--
作者：
Shi, Jinjie;Huang, Hua;Huang, Tony Jun
介绍了一种利用声表面波（SSAW）诱导声电泳在微流控通道中实现连续颗粒分离的方法。使用这种基于SSAW的方法，可以基于颗粒的体积、密度和压缩性来分离连续层流中的颗粒。在这项工作中，相同密度但不同体积的颗粒的混合物通过两个侧入口注入到微通道中，包围通过中心入口注入的去离子水鞘流。一个一维的SSAW产生的两个平行叉指换能器（IDT）建立跨通道，与跨一个单一的SSAW压力节点位于通道中心的通道。SSAW的应用在较大体积的颗粒上引起较大的轴向声力，将它们重新定位为更靠近通道中心处的波压力节点。因此，基于颗粒体积，颗粒横向移动到通道横截面的不同区域。这里介绍的颗粒分离方法简单而通用，能够以高分离效率和低功耗分离几乎所有种类的颗粒（无论电荷/偏振或光学性质如何）。
This work introduces a method of continuous particle separation through standing surface acoustic wave (SSAW)-induced acoustophoresis in a microfluidic channel. Using this SSAW-based method, particles in a continous laminar flow can be separated based on their volume, density and compressibility. In this work, a mixture of particles of equal density but dissimilar volumes was injected into a microchannel through two side inlets, sandwiching a deonized water sheath flow injected through a central inlet. A one-dimensional SSAW generated by two parallel interdigital transducers (IDTs) was established across the channel, with the channel spanning a single SSAW pressure node located at the channel center. Application of the SSAW induced larger axial acoustic forces on the particles of larger volume, repositioning them closer to the wave pressure node at the center of the channel. Thus particles were laterally moved to different regions of the channel cross-section based on particle volume. The particle separation method presented here is simple and versatile, capable of separating virtually all kinds of particles (regardless of charge/polarization or optical properties) with high separation efficiency and low power consumption.