Conducting Precision Medicine Research with African Americans.
Conducting Precision Medicine Research with African Americans.
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DOI：
10.1371/journal.pone.0154850
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Jefferson M
中科院分区：
文献类型：
--
作者：
Halbert CH;McDonald J;Vadaparampil S;Rice L;Jefferson M
精准医学是一种基于遗传、环境和生活方式因素的个体差异来检测、治疗和管理疾病的方法。精准医疗有望减少健康差距，但只有在研究中充分代表少数民族的情况下才有可能。随着研究计划的制定，预测来自不同人群的个体可能参与精准医学研究的比率至关重要。我们评估了参与精准医疗临床研究的可能性。2010年10月至2011年2月在非裔美国人的全国样本中进行的观察性研究。有意参与政府资助的研究，该研究涉及提供生物标本并生成可与其他研究人员共享的数据，以进行未来的研究。三分之一的受访者将参加精准医疗的临床研究。只有性别与参与意愿有显著的独立关联。在包括总体障碍和促进因素的模型中，男性参与精准医学研究的可能性比女性增加1.86（95% CI = 1.11，3.12，p = 0.02）。在具有特定参与障碍的模型中，不信任与参与小插曲中描述的研究的可能性降低相关（OR = 0.57，95%CI = 0.34，0.96，p = 0.04）。非裔美国人在PMI研究中的入学率可能很低。随着PMI研究的实施，将需要作出广泛努力，以确保充分的代表性。需要进行更多的研究，以确定在伦理上描述精准医学研究的最佳方式，以确保充分招募少数民族。
Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.