Anterior perirhinal cortex kindling produces long-lasting effects on anxiety and object recognition memory
Anterior perirhinal cortex kindling produces long-lasting effects on anxiety and object recognition memory
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DOI：
10.1111/j.1460-9568.2005.03938.x
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发表时间：
2005-02-01
影响因子：
3.4
通讯作者：
Corcoran, ME
中科院分区：
文献类型：
--
作者：
Hannesson, DK;Howland, JG;Corcoran, ME
颞叶癫痫（TLE）经常伴有记忆障碍，尽管其基础尚不清楚，但大多数研究都集中在海马体上。本研究以点火为模型，探讨了另一个内侧颞叶结构，即周围皮层（Prh）在TLE记忆变化中的重要性。大鼠每天用前路Prh刺激点燃两次，直到三次完全全身性癫痫发作。从7天后开始，连续几天对大鼠进行高架+迷宫、大圆形开阔场地、开阔场地物体探索任务和水迷宫延迟匹配-地点任务的测试，以评估焦虑相关和探索行为、物体识别记忆和空间认知。引火增加了在高场地迷宫和开阔场地迷宫中与焦虑相关的行为，破坏了自发的物体识别，但没有影响所有其他测试行为。这些结果与其他研究结果一致，表明Prh在物体记忆和情绪行为中比在空间记忆中发挥更大的作用，并与海马背侧点火对空间记忆的选择性破坏形成对比。由点火产生的行为中断的位点选择性表明，这种影响可能是由癫痫发作起始部位的特定变化介导的，而不是由边缘癫痫发作普遍化激活的特征电路的变化介导的。对Prh点燃的行为影响的进一步研究可能有助于研究与TLE相关的记忆和情感功能障碍的机制，并为患者之间这种功能障碍的变异性提供见解。
Temporal lobe epilepsy (TLE) is frequently accompanied by memory impairments and, although their bases are unknown, most research has focused on the hippocampus. The present study investigated the importance of another medial temporal lobe structure, the perirhinal cortex (Prh), in changes in memory in TLE using kindling as a model. Rats were kindled twice daily with anterior Prh stimulation until three fully generalized seizures were evoked. Beginning 7 days later and on successive days, rats were tested in an elevated plus maze, a large circular open field, an open field object exploration task and a delayed-match-to-place task in a water maze in order to assess anxiety-related and exploratory behaviour, object recognition memory and spatial cognition. Kindling increased anxiety-related behaviour in both the elevated plus and open field mazes and disrupted spontaneous object recognition but spared all other behaviours tested. These results are consistent with other findings indicating a greater role for the Prh in object memory and emotional behaviour than in spatial memory and contrast with the selective disruption of spatial memory produced by dorsal hippocampal kindling. The site-selectivity of the behavioural disruptions produced by kindling indicates that such effects are probably mediated by changes particular to the site of seizure initiation rather than to changes in the characteristic circuitry activated by limbic seizure generalization. Further investigation of the behavioural effects of Prh kindling may be useful for studying the mechanisms of mnemonic and affective dysfunction associated with TLE and offer insights into bases for variability in such dysfunction across patients.