Total synthesis of the indolocarbazole alkaloid ZHD-0501 and its seven isomers
Total synthesis of the indolocarbazole alkaloid ZHD-0501 and its seven isomers
复制标题
吲哚咔唑生物碱ZHD-0501及其七种异构体的全合成
DOI：
10.1039/d2qo00844k
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发表时间：
2022
影响因子：
5.4
通讯作者：
Weiming Zhu
中科院分区：
文献类型：
--
作者：
Liping Wang;Yapeng Zhang;Zhihong Xu;Jing Li;Weiming Zhu
以d/l-葡萄糖和2,3-二溴马来酰亚胺为原料，经过22步反应完全合成了吲哚并咔唑生物碱ZHD-0501（1）及其7种立体异构体（2-8），并首次证实了ZHD-0501的绝对构型。
An indolocarbazole alkaloid, ZHD-0501 (1), and its 7 stereoisomers (2–8) were totally synthesized from d / l -glucose and 2,3-dibromomaleimide in 22 step reactions, and the absolute configuration of ZHD-0501 was confirmed for the first time.