Adenosine triphosphate postconditioning is associated with better preserved global and regional cardiac function during myocardial ischemia and reperfusion: a speckle tracking imaging-based echocardiologic study
Adenosine triphosphate postconditioning is associated with better preserved global and regional cardiac function during myocardial ischemia and reperfusion: a speckle tracking imaging-based echocardiologic study
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三磷酸腺苷后处理与心肌缺血和再灌注期间更好地保存整体和局部心脏功能相关：一项基于斑点跟踪成像的超声心动图研究
DOI：
10.1111/1755-5922.12205
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发表时间：
2016-10-01
影响因子：
3.1
通讯作者：
Tian, Jiawei
中科院分区：
文献类型：
--
作者：
Ren, Min;Liu, Yujie;Tian, Jiawei
目的采用可逆性结扎兔冠状动脉左室分支建立心肌缺血/再灌注模型，应用超声斑点追踪技术评价缺血后处理（IPostC）和三磷酸腺苷（ATP）介导的药物后处理（ATP-PPostC）对心功能的影响。将家兔随机分为三组：缺血再灌注（IR）组（无进一步干预）、IPostC组和ATP-PPostC组。通过常规超声心动图和基于STI的超声心动图评价心功能。结果斑点追踪成像（STI）超声心动图显示，IPostC和ATP-PPostC与较好的整体和局部心功能保持相关，两组的GLSrsys、GLSrd、GLSsys、SrLsys、SrLd和SLsys均显著增加（均P
IntroductionEffects of ischemic postconditioning (IPostC) and adenosine triphosphate (ATP)-mediated pharmacologic postconditioning (ATP-PPostC) on cardiac function were evaluated by speckle tracking imaging (STI)-based echocardiography.AimsA myocardial I/R model was induced in rabbits by reversible ligation of the left ventricular branch of coronary artery. Rabbits were randomized into three groups: ischemia and reperfusion (IR) (no further intervention), IPostC, and ATP-PPostC groups. Cardiac function was evaluated by conventional and STI-based echocardiography. Myocardial necrosis, apoptosis, and myocardial mRNAs of apoptosis-related proteins (Bcl-2 and Bax) were evaluated.ResultsSpeckle tracking imaging (STI)-based echocardiography revealed that IPostC and ATP-PPostC were associated with better preserved global and regional cardiac function, as indicated by significantly increased GLSrsys, GLSrd, GLSsys, SrLsys, SrLd, and SLsys in both groups (all P