Orexin/hypocretin is necessary for context-driven cocaine-seeking.
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
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DOI：
10.1016/j.neuropharm.2009.06.042
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发表时间：
2010-01
影响因子：
4.7
通讯作者：
Aston-Jones G
中科院分区：
文献类型：
--
作者：
Smith RJ;Tahsili-Fahadan P;Aston-Jones G
食欲素1受体（OX 1 R）的食欲素/下丘脑分泌素信号转导最近被认为与成瘾和复发有关。我们研究了食欲素系统在可卡因寻求引起的药物相关的情况下，从慢性可卡因自我管理禁欲或灭绝的作用。雄性Sprague-Dawley大鼠以2小时的时间段自我施用可卡因，持续10天，然后在饲养笼中进行消退训练或延长禁欲。OX 1 R拮抗剂SB-334867（SB; 10、20或30 mg/kg，i. p.）在再次暴露于可卡因自我施用环境之前施用。我们发现，SB预处理显着衰减可卡因寻求时，大鼠被放回自我管理的环境后，无论是1天或2周的禁欲（没有灭绝），或灭绝后的可卡因寻求在一个替代的环境（不同于训练环境）。这些结果表明，食欲素信号在OX 1 R是关键的条件可卡因寻求引起的药物相关的背景下，无论是灭绝或禁欲。
Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats self-administered cocaine in 2-hour sessions for 10 days, followed by extinction training or extended abstinence in the home cage. The OX1R antagonist SB-334867 (SB; 10, 20, or 30 mg/kg, i.p.) was administered prior to re-exposure to the cocaine self-administration environment. We found that pretreatment with SB significantly attenuated cocaine-seeking when rats were placed back into the self-administration environment following either 1 day or 2 weeks of abstinence (no extinction), or following extinction of cocaine-seeking in an alternative environment (distinct from the training environment). These results indicate that orexin signaling at OX1R is critical for conditioned cocaine-seeking elicited by a drug-associated context, following either extinction or abstinence.
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影响因子：
3.4
作者：
Richards, Jemma K.;Simms, Jeffrey A.;Steensland, Pia;Taha, Sharif A.;Borgland, Stephanie L.;Bonci, Antonello;Bartlett, Selena E.
通讯作者：
Bartlett, Selena E.
影响因子：
3.4
作者：
McLaughlin, J;See, RE
通讯作者：
See, RE
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
64.5
作者：
Lin, L;Faraco, J;Mignot, E
通讯作者：
Mignot, E