Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood
Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood
复制标题
DOI：
10.1162/jocn.2007.19.5.750
复制
发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Klingberg, Torkel
中科院分区：
文献类型：
--
作者：
Edin, Fredrik;Macoveanu, Jufian;Klingberg, Torkel
儿童时期认知发展背后的细胞成熟过程，包括工作记忆能力的发展，仍然是未知的。通过使用最标准的视觉空间工作记忆的计算模型，我们研究了细胞成熟过程的后果，包括髓鞘形成，突触强化和突触修剪，对工作记忆相关的大脑活动和性能。我们实现了五个结构的发展变化发生的结果，在生物药理学为基础的计算网络模型的细胞成熟过程。然后将模型模拟预测的记忆活动的发展变化与儿童和成人的功能性磁共振成像测量的大脑活动进行比较。我们发现，在编码类似刺激的细胞之间具有更强的额顶叶突触连接的网络，而不是那些具有更快的传导、更强的区域内连接或增加的编码特异性的网络，可以预测与工作记忆相关的大脑活动和区域间活动相关性的测量发育增加。因此，编码类似刺激的细胞之间更强的额顶叶突触连接是唯一的发育过程，可以解释观察到的与儿童时期工作记忆发展相关的大脑活动变化。
The cellular maturational processes behind cognitive development during childhood, including the development of working memory capacity, are still unknown. By using the most standard computational model of visuospatial working memory, we investigated the consequences of cellular maturational processes, including myelination, synaptic strengthening, and synaptic pruning, on working memory-related brain activity and performance. We implemented five structural developmental changes occurring as a result of the cellular maturational processes in the biophysically based computational network model. The developmental changes in memory activity predicted from the simulations of the model were then compared to brain activity measured with functional magnetic resonance imaging in children and adults. We found that networks with stronger fronto-parietal synaptic connectivity between cells coding for similar stimuli, but not those with faster conduction, stronger connectivity within a region, or increased coding specificity, predict measured developmental increases in both working memory-related brain activity and in correlations of activity between regions. Stronger fronto-parietal synaptic connectivity between cells coding for similar stimuli was thus the only developmental process that accounted for the observed changes in brain activity associated with development of working memory during childhood.