Correlation of Carbon Dots' Light-Activated Antimicrobial Activities and Fluorescence Quantum Yield.
Correlation of Carbon Dots' Light-Activated Antimicrobial Activities and Fluorescence Quantum Yield.
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作者：
Al Awak MM;Wang P;Wang S;Tang Y;Sun YP;Yang L
本研究考察了以2,2′-（乙二氧基）双（乙胺）为表面功能化分子特异性制备的一系列碳点（EDA-CDots）的光激活抗菌功能，其荧光量子产率（ΦF）范围为7.5% ~ 27%。结果表明，CDots光激活杀菌功能的有效性与其观测到的ΦF值相关。这些EDA-CDots对革兰氏阴性和革兰氏阳性模式细菌（分别为大肠杆菌和枯草芽孢杆菌）的抗菌活性也在不同的实验参数（包括点浓度和处理时间）的条件下进行了评估。探讨了选择ΦF、浓度和处理时间对EDA-CDots杀菌效果的影响，并对其机理进行了讨论。碳点的抗菌性能与它们的光激发态特性有关。
This study investigated the photo-activated antibacterial function of a series of specifically prepared carbon dots with 2,2’-(ethylenedioxy)bis(ethylamine) as the surface functionalization molecule (EDA-CDots), whose fluorescence quantum yields (ΦF) ranged from 7.5% to 27%. The results revealed that the effectiveness of CDots’ photo-activated bactericidal function was correlated with their observed ΦF values. The antimicrobial activities of these EDA-CDots against both Gram negative and Gram positive model bacterial species (E. coli and Bacillus subtilis, respectively) were also evaluated under conditions of varying other experimental parameters including dot concentrations and treatment times. Optimization of the bactericidal effect of the EDA-CDots by a combination of the selected ΦF, concentration and treatment time was explored, and mechanistic implications of the results are discussed. The antibacterial performance of carbon dots is correlated with their photoexcited state properties for mechanistic elucidation.