Random genetic drift determines the level of mutant mtDNA in human primary oocytes
Random genetic drift determines the level of mutant mtDNA in human primary oocytes
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DOI：
10.1086/318190
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发表时间：
2001-02-01
影响因子：
9.8
通讯作者：
Chinnery, PF
中科院分区：
文献类型：
--
作者：
Brown, DT;Samuels, DC;Chinnery, PF
我们测量了一名携带A3243G线粒体DNA突变的女性的82个初级卵母细胞中突变型线粒体DNA的比例（突变负荷）。突变负荷的频率分布表明，随机漂变是决定单个卵母细胞内突变型线粒体DNA水平的主要机制。
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.