Association of Choroidal Thickness with Intermediate Age-Related Macular Degeneration in a Japanese Population
Association of Choroidal Thickness with Intermediate Age-Related Macular Degeneration in a Japanese Population
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DOI：
10.1016/j.oret.2020.09.001
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发表时间：
2021-06-04
影响因子：
4.5
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
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作者：
Sasaki, Mariko;Ito, Yoshikazu;Tsubota, Kazuo
目的：确定日本人群中脉络膜厚度与年龄相关性黄斑变性 (AMD) 早期阶段及其疾病特征的关系。设计：横断面调查。参与者：居住在佐久地区的 1293 名 65 至 86 岁日本人，作为日本公共卫生中心前瞻性研究的一部分，接受了眼部筛查。方法：综合眼科评估包括眼底照相、眼压测量和眼压测定。屈光状态。进行了增强深度成像模式的 OCT 并评估了中心凹下脉络膜厚度。在调整潜在混杂因素后，采用多项 Logistic 回归模型评估脉络膜厚度与 AMD 早期（即早期 AMD 和中期 AMD）及其疾病特征的关系。主要结果指标：脉络膜厚度与早期 AMD、中期 AMD 及其疾病特征的关系。结果：在 1293 名潜在参与者中，901 名（平均年龄，73.2 岁）拥有脉络膜厚度数据、足够质量的眼底照片，并且没有伴随视网膜疾病（包括 5 例晚期 AMD）。平均脉络膜厚度为246.1μm，15.1％患有早期AMD，9.0％患有中期AMD。调整年龄、性别和屈光状态后，脉络膜厚度与中期 AMD 的存在呈正相关（每增加 1 个标准差 [SD] mm：比值比 [OR]，1.43；95% 置信区间 [CI]，1.13-1.81），而与早期 AMD 的存在没有显着相关性。在中间 AMD 特征中，脉络膜厚度与 AMD 色素异常的存在呈正相关（至少与中等玻璃膜疣相关；每增加 1-SD μm：OR，2.21；95% CI，1.42-3.42），而与单独存在大玻璃膜疣没有显着相关性。此外，在大玻璃膜疣亚型中，脉络膜厚度与 pacHydrusen 的存在呈正相关（每增加 1-SD mm：OR，1.53；95% CI，1.10-2.13）。此外，探索性分析显示，脉络膜厚度与非 AMD 色素异常的存在呈正相关（每增加 1-SD mm：OR，1.92；95% CI，1.31-2.18）。结论：脉络膜厚度似乎与亚洲人中期 AMD 的病理学及其特征相关。 (C) 2020 年美国眼科学会
Purpose: To determine the relationship of choroidal thickness with the early stages of age-related macular degeneration (AMD) and their disease features in a Japanese population.Design: Cross-sectional survey.Participants: A total of 1293 Japanese persons 65 to 86 years of age residing in the Saku area who underwent eye screening as part of the Japan Public Health Center-based Prospective Study.Methods: Comprehensive ophthalmic assessment included fundus photography, measurement of intraocular pressure, and determination of refractive status. OCT with enhanced depth imaging mode was performed and subfoveal choroidal thickness was assessed. Multinomial logistic regression models were used to assess the relationships of choroidal thickness with the early stages of AMD, namely early AMD and intermediate AMD, and their disease features, after adjustment for potential confounders.Main Outcome Measures: Relationship of choroidal thickness with early AMD, intermediate AMD, and their disease features.Results: Of 1293 potential participants, 901 (mean age, 73.2 years) had choroidal thickness data, fundus photographs of sufficient quality, and no concomitant retinal disease (including 5 with late AMD). Mean choroidal thickness was 246.1 mu m, 15.1% had early AMD, and 9.0% had intermediate AMD. After adjustment for age, gender, and refractive status, choroidal thickness was associated positively with presence of intermediate AMD (for each 1- standard deviation [SD] mm increase: odds ratio [OR], 1.43; 95% confidence interval [CI], 1.13-1.81), whereas no significant association was found with presence of early AMD. Among intermediate AMD features, choroidal thickness was associated positively with presence of AMD pigmentary abnormalities (associated with at least medium drusen; for each 1-SD mu m increase: OR, 2.21; 95% CI, 1.42-3.42), whereas no significant association was found with presence of large drusen alone. In addition, among large drusen subtypes, choroidal thickness was associated positively with presence of pachydrusen (for each 1-SD mm increase: OR, 1.53; 95% CI, 1.10-2.13). Furthermore, exploratory analysis revealed that choroidal thickness was associated positively with presence of non-AMD pigmentary abnormalities (for each 1-SD mm increase: OR, 1.92; 95% CI, 1.31-2.18).Conclusions: Choroidal thickness seems to be associated with the pathology of intermediate AMD and its features in Asians. (C) 2020 by the American Academy of Ophthalmology