Alligators as West Nile virus amplifiers
Alligators as West Nile virus amplifiers
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DOI：
10.3201/eid1012.040264
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发表时间：
2004-12-01
影响因子：
11.8
通讯作者：
Bunning, M
中科院分区：
文献类型：
--
作者：
Klenk, K;Snow, J;Bunning, M
最近的证据表明，美洲短吻鳄（Alligator mississippiensis）可能能够将西尼罗河病毒（WNV）传播给其他短吻鳄。我们实验暴露24少年短吻鳄西尼罗河病毒胃肠外或口服。所有人都被感染了，除了三个人之外，所有人都持续病毒血症滴度>5.0 log（10）PFU/mL（被认为是致倦库蚊感染的阈值）1至8天。未接种疫苗的队友也被感染。病毒血症的档案和多种途径的感染表明，短吻鳄可能发挥重要作用，在西尼罗河病毒传播的地区，高人口密度的少年短吻鳄。
Recent evidence suggests that American alligators (Alligator mississippiensis) may be capable of transmitting West Nile virus (WNV) to other alligators. We experimentally exposed 24 juvenile alligators to WNV parenterally or orally. All became infected, and all but three sustained viremia titers >5.0 log(10) PFU/mL (a threshold considered infectious for Culex quinquetasciatus mosquitoes) for 1 to 8 days. Noninoculated tankmates also became infected. The viremia profiles and multiple routes of infection suggest alligators may play an important role in WNV transmission in areas with high population densities of juvenile alligators.