Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway
Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway
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DOI：
10.1038/modpathol.3800976
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发表时间：
2008-01-01
期刊：
影响因子：
7.5
通讯作者：
Nielsen, Torsten O.
中科院分区：
文献类型：
--
作者：
Steigen, Sonja E.;Bjerkehagen, Bodil;Nielsen, Torsten O.
胃肠道间质瘤(GIST)是胃肠道最常见的间叶性肿瘤。GIST的诊断是基于组织学和一组免疫组织化学标志物；最重要的是KIT(CD117)。共有434例GIST经组织学和免疫组织化学证实，并整合到组织芯片中。对两种免疫组织化学标志物(p16和L1)的组织学特征和预后价值进行评估。高有丝分裂率、肿瘤大小、核异型性和小肠原发部位都是GISTS的负面预后因素。P16的表达与预后不良密切相关，而L1的表达与预后无关。
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract. The diagnosis of GIST is based on histology together with a panel of immunohistochemical markers; the most important is KIT (CD117). A total of 434 cases of GISTs were confirmed by histology and immunohistochemistry, and incorporated into tissue microarrays. Validation of histological features as well as the prognostic value of two immunohistochemical biomarkers (p16 and L1) was assessed. High mitotic rate, large tumor size, nuclear atypia, and small bowel primary site were all validated as negative prognostic factors in GISTs. Expression of p16 was significantly correlated with unfavorable prognosis, whereas L1 expression was not.