Tau epitope display in progressive supranuclear palsy and corticobasal degeneration
Tau epitope display in progressive supranuclear palsy and corticobasal degeneration
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DOI：
10.1023/b:neur.0000044190.96426.b9
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发表时间：
2004-05-01
期刊：
影响因子：
--
通讯作者：
Binder, LI
中科院分区：
文献类型：
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作者：
Berry, RW;Sweet, AP;Binder, LI
蛋白tau的丝状聚集体是阿尔茨海默病（AD）、进行性核上性麻痹（PSP）和皮质基底变性（CBD）的一个显著特征。然而，在这些疾病之间，这些聚集体中tau蛋白的分子结构在多大程度上相似或不同尚不清楚。我们通过使用一组代表不同结构、构象和切割特异性tau表位的抗体来检查这些疾病来解决这个问题。虽然这些抗体都显示AD病理，但它们在PSP和CBD方面分为三类：AD2和tau -46.1在所有病例中染色最多的tau病理；Tau-1、2、5和12表现出可变反应性；tau -66和MN423未显示任何tau病理。此外，这些病例的海马神经原纤维缠结主要显示PSP/ cbd样染色模式，而不是ad样染色模式。这些结果表明，该小组所代表的tau表位模式存在于PSP和CBD的病理聚集体中，彼此相似，但与AD不同。
Filamentous aggregates of the protein tau are a prominent feature of Alzheimer's disease ( AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). However, the extent to which the molecular structure of the tau in these aggregates is similar or differs between these diseases is unclear. We approached this question by examining these disorders with a panel of antibodies that represent different structural, conformational, and cleavage-specific tau epitopes. Although each of these antibodies reveals AD pathology, they resolved into three classes with respect to PSP and CBD: AD2 and Tau-46.1 stained the most tau pathology in all cases; Tau-1, 2, 5, and 12 exhibited variable reactivity; and Tau-66 and MN423 did not reveal any tau pathology. In addition, hippocampal neurofibrillary tangles in these cases showed a predominantly PSP/CBD-like, rather than AD-like, staining pattern. These results indicate that the patterns of the tau epitopes represented by this panel that reside in the pathological aggregates of PSP and CBD are similar to each other but distinct from that of AD.