PILUS EXPRESSION IN NEISSERIA-GONORRHOEAE INVOLVES CHROMOSOMAL REARRANGEMENT
PILUS EXPRESSION IN NEISSERIA-GONORRHOEAE INVOLVES CHROMOSOMAL REARRANGEMENT
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DOI：
10.1016/0092-8674(82)90010-1
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发表时间：
1982-01-01
期刊：
影响因子：
64.5
通讯作者：
SO, M
中科院分区：
文献类型：
--
作者：
MEYER, TF;MLAWER, N;SO, M
了N.淋病菌毛蛋白是细胞表面的主要抗原决定簇之一。它由. apprx的相同亚基组成。18 kd [千道尔顿]，并在生物体的感染性和毒力中发挥作用。将编码淋球菌菌毛蛋白的基因克隆到大肠杆菌中，用其中一个克隆作探针进行杂交研究，结果表明，淋球菌菌毛阳性向阴性的转变是由细菌的菌毛阳性向阴性的转变引起的。淋病涉及染色体重排。虽然菌毛蛋白是由E.在大肠杆菌中，它似乎没有以天然形式组装在细胞表面。
The N. gonorrhoeae pilus protein is one of the major antigenic determinants on the cell''s surface. It is composed of identical subunits of .apprx. 18 kd [kilodaltons] and plays a role in the infectivity and virulence of the organism. The gene encoding a gonococcal pilus protein was cloned into Escherichia coli, and, using one of these clones as a probe in hybridization studies, it was shown that conversion of the pilus positive to pilus negative state in N. gonorrhoeae involves chromosomal rearrangement. Although the pilus protein is produced by E. coli, it does not appear to be assembled on the surface of the cell in native form.