IMMUNOELECTRONMICROSCOPIC STUDY OF α‐FETOPROTEIN SYNTHESIS IN HEPATOMA CELLS
IMMUNOELECTRONMICROSCOPIC STUDY OF α‐FETOPROTEIN SYNTHESIS IN HEPATOMA CELLS
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肝癌细胞α-胎蛋白合成的免疫电镜研究
DOI：
10.1111/j.1749-6632.1975.tb25415.x
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发表时间：
1975
影响因子：
5.2
通讯作者：
T. Shikata
中科院分区：
文献类型：
--
作者：
T. Shikata
在肝癌细胞中，发现AFP合成通过粗面内质网的核糖体发生，因为通过过氧化物酶抗体技术证实AFP围绕粗面内质网的核糖体。分泌过程中，滑面内质网参与，高尔基体不参与。关于3 'Me-DAB诱发肝癌过程中AFP的早期短暂出现，AFP可能是由胆管和肝细胞索之间的增殖的壶腹细胞产生的。
In the hepatoma cells, AFP synthesis was found to occur through ribosomes of the rough endoplasmic reticulum, since AFP was demonstrated around ribosomes of the rough endoplasmic reticulum by the peroxidase antibody technique. The secretory process was suggested to be as follows: smooth endoplasmic reticulum takes a part and the Golgi apparatus does not. Concerning the early transitory appearance of AFP in the course of hepatocarcinogenesis by 3'Me-DAB, AFP might be produced by proliferated ampulla cells, which exist between the cholangioles and liver cell cords.