Regulation of transport in the connecting tubule and cortical collecting duct.
Regulation of transport in the connecting tubule and cortical collecting duct.
复制标题
调节连接小管和皮质收集管中的转运。
DOI：
10.1002/cphy.c110052
复制
发表时间：
2012-04
影响因子：
5.8
通讯作者：
Staruschenko A
中科院分区：
文献类型：
--
作者：
Staruschenko A
这篇综述文章的中心目标是总结肾上皮运输的最新发现，主要集中在连接小管（CNT）和皮质集管（CCD）。哺乳动物CCD和碳纳米管通过重吸收和分泌参与电解质和液体平衡的微调。特定的转运体和通道介导这些节段中水和溶质的矢量运动。虽然只有一小部分肾小球滤液到达CNT和CCD，但由于醛固酮和精氨酸加压素等多种激素在这些肾元部位发挥主要作用，这些段对水和电解质的稳态至关重要。重要的是，激素通过影响CNT和CCD中的通道和转运体来调节整个肾元和肾脏的功能。在过去的二十年中，关于碳纳米管和CCD转运的生理和病理生理调节以及特定通道/转运体的特殊作用的知识已经大大增加。最近的研究揭示了有关肾脏转运调节的几个关键问题。本文将回顾CCD和碳纳米管中转运蛋白的精确分布模式，以及它们在这些片段中介导离子转运的生理作用和机制。特别强调的是由于CNT和CCD的肾转运异常而出现的病理生理状况。
The central goal of this overview article is to summarize recent findings in renal epithelial transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct (CCD). Mammalian CCD and CNT are involved in fine tuning of electrolyte and fluid balance through reabsorption and secretion. Specific transporters and channels mediate vectorial movements of water and solutes in these segments. Although only a small percent of the glomerular filtrate reaches the CNT and CCD, these segments are critical for water and electrolyte homeostasis since several hormones, e.g. aldosterone and arginine vasopressin, exert their main effects in these nephron sites. Importantly, hormones regulate the function of the entire nephron and kidney by affecting channels and transporters in the CNT and CCD. Knowledge about the physiological and pathophysiological regulation of transport in the CNT and CCD and particular roles of specific channels/transporters has increased tremendously over the last two decades. Recent studies shed new light on several key questions concerning the regulation of renal transport. Precise distribution patterns of transport proteins in the CCD and CNT will be reviewed, and their physiological roles and mechanisms mediating ion transport in these segments will be also covered. Special emphasis will be given to pathophysiological conditions appearing as a result of abnormalities in renal transport in the CNT and CCD.
登录
查看更多内容
影响因子：
64.8
作者：
Barr, MM;Sternberg, PW
通讯作者：
Sternberg, PW
影响因子：
7
作者：
Barile, M;Pisitkun, T;Knepper, MA
通讯作者：
Knepper, MA
影响因子：
11.4
作者：
Abe, Kazuhiro;Tani, Kazutoshi;Fujiyoshi, Yoshinori
通讯作者：
Fujiyoshi, Yoshinori
影响因子：
3.9
作者：
Azad, Abul Kalam;Rauh, Robert;Cuppens, Harry
通讯作者：
Cuppens, Harry
影响因子：
5.5
作者：
Arreola, J;Begenisich, T;Melvin, JE
通讯作者：
Melvin, JE