Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
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血清骨桥蛋白对特发性肺纤维化急性加重的预后价值
DOI：
10.1155/2020/3424208
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发表时间：
2020-02-10
影响因子：
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通讯作者：
Cai, Hourong
中科院分区：
文献类型：
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作者：
Gui, Xianhua;Qiu, Xiaohua;Cai, Hourong
背景。急性加重（AE）是特发性肺纤维化（IPF）患者快速恶化和高死亡率的常见原因。骨桥蛋白（Osteopontin， OPN）在IPF中起重要作用，但对AE-IPF中血清OPN的研究尚不清楚。我们的目的是研究OPN是否对IPF的急性加重和死亡率有潜在的预后价值。方法。纳入32例AE-IPF患者，39例S-IPF患者和20例健康对照。AE-IPF组与S-IPF组比较血清OPN和KL-6水平。采用Logistic回归分析确定OPN对AE的预测值。Kaplan-Meier曲线用于显示生存率，Cox比例风险回归用于确定死亡风险。结果。AE-IPF患者血清OPN水平显著高于S-IPF患者(p
Background. Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potential prognostic value in acute exacerbation and mortality in IPF. Methods. Thirty-two patients with AE-IPF, 39 with S-IPF, and 20 healthy controls were included. Serum OPN and KL-6 levels were compared between AE-IPF and S-IPF. Logistic regression analysis was applied to identify the predicted value of OPN for AE. Kaplan-Meier curves were used to display survival, and Cox proportional hazards regression was used to identify risk for mortality. Results. In AE-IPF patients, serum OPN levels were significantly higher than in S-IPF subjects (p