Alterations in the postnatal development of striatal preprotachykinin but not preproenkephalin mRNA expression in the serotonin-depleted rat.
Alterations in the postnatal development of striatal preprotachykinin but not preproenkephalin mRNA expression in the serotonin-depleted rat.
复制标题
血清素耗尽大鼠中纹状体前原速激肽的出生后发育发生变化，但前脑啡肽原 mRNA 表达没有变化。
DOI：
10.1159/000111199
复制
发表时间：
1997
影响因子：
2.9
通讯作者：
Wolf,WA
中科院分区：
文献类型：
--
作者：
Walker,PD;Wolf,WA
We examined the effects of diminished serotonin (5-hydroxytryptamine, 5-HT) levels on the postnatal development of striatal tachykinin and enkephalin neuropeptide systems. Neonatal rats received intracisternal injection of vehicle or the 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT; 100 pg) on postnatal day 2 followed by sacrifice 1–29 days later. Monoamine analysis by high-performance liquid chromatography with electrochemical detection revealed a drastic reduction of midbrain 5-HT levels, but not norepinephrine or dopamine, as early as 1 day and extending to 29 days following 5,7-DHT injection. Striatal preprotachykinin (PPT) mRNA levels were significantly increased 8 days following injection. However, PPT mRNA amounts failed to remain up-regulated, falling back to or below control levels during the second and third weeks following injection. By day 29, striatal PPT mRNA had normalized to control levels even though 5-HT amounts were still markedly reduced. Throughout the entire time course, striatal preproenkephalin mRNA levels did not significantly differ from control levels. These results suggest that striatal tachykinin, but not enkephalin, neurons may be transiently sensitive to lowered 5-HT neurotransmission during postnatal development.
