Cooperativity, sensitivity, and noise in biochemical signaling
Cooperativity, sensitivity, and noise in biochemical signaling
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DOI：
10.1103/physrevlett.100.258101
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发表时间：
2008-06-27
影响因子：
8.6
通讯作者：
Setayeshgar, Sima
中科院分区：
文献类型：
--
作者：
Bialek, William;Setayeshgar, Sima
多种信号分子结合中的协同相互作用是提高生物信号系统敏感性的一种常见机制。人们普遍认为，平均响应灵敏度的提高意味着能够检测到较小的信号。扩展Berg和Purcell的经典工作[生物物理学]。J. 20, 193(1977)]在化学接受的物理限制上，我们表明扩散信号分子随机到达受体位点构成了一个噪声源，该噪声源不会因协同性而减少。协作性使达到这个极限更容易，但不能降低极限本身。
Cooperative interactions in the binding of multiple signaling molecules is a common mechanism for enhancing the sensitivity of biological signaling systems. It is widely assumed this increase in sensitivity of the mean response implies the ability to detect smaller signals. Extending the classic work of Berg and Purcell [Biophys. J. 20, 193 (1977)] on the physical limits of chemoreception, we show that the random arrival of diffusing signaling molecules at receptor sites constitutes a noise source that is not reduced by cooperativity. Cooperativity makes reaching this limit easier, but cannot reduce the limit itself.