Synthesis and characterization of a novel double cross-linked hydrogel based on Diels-Alder click reaction and coordination bonding
Synthesis and characterization of a novel double cross-linked hydrogel based on Diels-Alder click reaction and coordination bonding
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DOI：
10.1016/j.msec.2017.08.031
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发表时间：
2018-01-01
影响因子：
7.9
通讯作者：
Wang, Zhenyu
中科院分区：
文献类型：
--
作者：
Li, Shubin;Wang, Lu;Wang, Zhenyu
水凝胶是一种很有前途的生物材料，既要有很强的力学性能，又要有内在的自愈性能。在这项工作中，通过结合Diels-Alder点击反应和配位效应，设计并制备了一种双交联型网络水凝胶。该水凝胶具有良好的热力学性能、抗EDTA性能和自愈性能。此外，通过调节Fe-3(+)-邻苯二酚的比例，可以控制水凝胶的力学性能、溶胀性能和表面形态。调节pH值可以改变水凝胶的颜色、交联方式和力学性能。这种利用DA点击化学和配位效应创造的智能水凝胶对设计具有良好力学性能、自愈性能和可控交联度的新型水凝胶具有指导意义。
Hydrogels, promising biological materials, need to have both strong mechanical properties and also inherent self-healing properties. In this work a double cross-linked network (DN) hydrogel was designed and prepared by combining a Diels-Alder click reaction and coordination effects. This DN hydrogel had good thermodynamic properties, anti-EDTA performance and self-healing properties. In addition, the mechanical properties, swelling properties and surface morphology of DN hydrogels can be controlled by adjusting the ratio of Fe-3 (+)-catechol. The adjustment of pH value can change the color, crosslinking mode and mechanical properties of the DN hydrogel. This smart hydrogel created from DA click chemistry and coordination effects has significance for guiding the design of new hydrogels with good mechanical properties, self-healing properties and controlled cross-link density.