Does the representation of time depend on the cerebellum? Effect of cerebellar stroke
Does the representation of time depend on the cerebellum? Effect of cerebellar stroke
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DOI：
10.1093/brain/awh065
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发表时间：
2004-03-01
期刊：
影响因子：
14.5
通讯作者：
Knight, RT
中科院分区：
文献类型：
--
作者：
Harrington, DL;Lee, RR;Knight, RT
小脑损伤后，似乎依赖于处理时间信息的行为经常受到干扰。本研究检查了小脑在外显计时中的作用及其与其他心理过程的关系。我们假设，如果小脑调节计时操作，那么小脑损伤就会破坏时间间隔的感知和再现，因为两者都被认为是由共同的计时机制支持的。 21 名中风小脑损伤患者和 30 名正常对照者执行了时间感知和时间再现任务。在时间再现任务中，计时可变性被分解为中央计时分量（时钟可变性）和运动分量（运动实现可变性）。我们发现，小脑中上小叶内侧和外侧损伤的患者仅在时间再现方面存在障碍（时钟变异性增加）。为了探索时间处理缺陷的潜在原因，时间再现和感知表现与注意力、工作记忆、感觉辨别和处理速度的独立测量相关。较差的工作记忆与时间再现的“时钟”部分的可变性增加相关。相比之下，处理速度与时间感知的相关性最好。结果不支持小脑在计时操作中的作用。相反，计时运动的缺陷可能与获取与任务相关的感觉和认知信息的中断以及运动输出系统的额外损伤有关。
Behaviours that appear to depend on processing temporal information are frequently disrupted after cerebellar damage. The present study examined the role of the cerebellum in explicit timing and its relationship to other psychological processes. We hypothesized that if the cerebellum regulates timekeeping operations then cerebellar damage should disrupt the perception and the reproduction of intervals, since both are thought to be supported by a common timekeeper mechanism. Twenty-one patients with cerebellar damage from stroke and 30 normal controls performed time perception and time reproduction tasks. In the time reproduction task, timing variability was decomposed into a central timing component (clock variability) and a motor component (motor implementation variability). We found impairments only in time reproduction (increased clock variability) in patients with medial and lateral damage involving the middle- to superior-cerebellar lobules. To explore potential reasons for the temporal processing deficits, time reproduction and perception performance were correlated with independent measures of attention, working memory, sensory discrimination and processing speed. Poorer working memory correlated with increased variability in the 'clock' component of time reproduction. In contrast, processing speed correlated best with time perception. The results did not support a role for the cerebellum in timekeeping operations. Rather, deficits in timing movements may be related to a disruption in acquiring sensory and cognitive information relevant to the task, coupled with an additional impairment in the motor-output system.