Structural features of prolactins and growth hormones that can be related to their biological properties.
Structural features of prolactins and growth hormones that can be related to their biological properties.
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催乳素和生长激素的结构特征与其生物学特性相关。
DOI：
10.1210/edrv-7-2-169
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发表时间：
1986
影响因子：
20.3
通讯作者：
S. Russell
中科院分区：
文献类型：
--
作者：
C. S. Nicoll;G. Mayer;S. Russell
本文比较了8种哺乳动物和家鸡GH的氨基酸序列与7种哺乳动物PRL的氨基酸序列。个别氨基酸，残基簇，和区域的分子被确定为高度保守的所有激素。鉴定了仅对PRL或仅对GH具有特异性的其他单个氨基酸、残基簇和区域。尝试将这些特定的和通常保守的特征与PRL、GH和胎盘催乳素（PL）的特定的和共享的生物学特性相关联，方法是将它们与预测的二级结构和亲水性分析相关联。后者涉及基于区域的疏水性或亲水性来预测分子的哪些区域将是内部或外部。保守残基的外部集群（包括特定的和共同保守的）被确定，可以特异性地关联到基因组。
IN THIS review we have compared the amino acid sequences of the GHs of eight mammalian species and the domestic chicken with the sequences of the PRLs of seven mammalian species. Individual amino acids, clusters of residues, and regions of the molecules were identified that were highly conserved among all of the hormones. Other individual amino acids, clusters of residues, and regions were identified that were specific to PRLs only or to GHs only. Attempts were made to associate these hormone-specific and commonly conserved features to the hormone-specific and shared biological properties of PRLs, GHs, and placental lactogens (PLs) by relating them to predicted secondary structure and hydropathy analysis. The latter involves predicting which regions of the molecules would be interior or exterior, based on the hydrophobicity or hydrophilicity of the regions. External clusters of conserved residues (consisting of both hormone-specific and commonly conserved) were identified that could be specifically associ...