SELECTIVE PERMEABILITY CHANGES IN THE LUNGS AND AIRWAYS OF SHEEP AFTER TOXIC SMOKE-INHALATION
SELECTIVE PERMEABILITY CHANGES IN THE LUNGS AND AIRWAYS OF SHEEP AFTER TOXIC SMOKE-INHALATION
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DOI：
10.1152/jappl.1990.68.5.2165
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发表时间：
1990-05-01
影响因子：
3.3
通讯作者：
HERNDON, DN
中科院分区：
文献类型：
--
作者：
BARROW, RE;MORRIS, SE;HERNDON, DN
研究了吸入有毒烟雾对成年羊微血管选择性筛选大分子和淋巴蛋白通量的影响，以确定肺和气管微血管功能障碍的时间进程是否不同。吸入棉花不完全燃烧产物48小时后，肺部蛋白质通量增加了6倍，而吸入棉花不完全燃烧产物8小时后，气管蛋白质通量增加了5倍，48小时后恢复到接近基线的水平。肺和气管选择性地保留了对三种不同的蛋白质大分子的筛分，分子半径分别为36、54和123 ang。这些大分子在损伤后48 h在肺中具有选择性，在损伤后8 h在气管中具有选择性。这些数据表明，气管和肺的微血管损伤的时间过程不同；气管微血管的改变比肺部更早被发现。因此，所描述的吸入性损伤允许表征气道和肺微血管变化的时间过程。
The effect of toxic smoke inhalation on selective microvascular sieving of macromolecules and lymph protein flux was assessed in adult sheep to determine whether the time course of microvascular dysfunction differs between the lung and trachea. Protein flux across the lung increased sixfold 48 h after inhalation of the products of incomplete cotton combustion, whereas tracheal protein flux increeased five fold 8 h after exposure and returned to near base line 48 h after exposure. The lung and trachea selectively retained some sieving to three different protein macromolecules with molecular radii of 36, 54, and 123 .ANG.. In the lungs the sieving selectivity for these macromolecules was least 48 h after injury, and in the trachea molecular selectively was least 8 h after injury. These data suggest that the the time course of microvascular injury differs for the trachea and the lung; microvascular changes are detected earlier in the trachea than in the lung. The inhalation injury described thus permits the characterization of the time course of airway and lung microvascular changes.